Extraction and Inhibition of Enzymatic Activity of Botulinum Neurotoxins/A1, /A2, and /A3 by a Panel of Monoclonal Anti-BoNT/A Antibodies

Suzanne R. Kalb; Jianlong Lou; Consuelo Garcia-Rodriguez; Isin N. Geren; Theresa J. Smith; Hercules Moura; James D. Marks; Leonard A. Smith; James L. Pirkle; John R. Barr

doi:10.1371/journal.pone.0005355

Loading metrics

Open Access

Peer-reviewed

Research Article

Extraction and Inhibition of Enzymatic Activity of Botulinum Neurotoxins/A1, /A2, and /A3 by a Panel of Monoclonal Anti-BoNT/A Antibodies

Suzanne R. Kalb,

Affiliation Centers for Disease Control and Prevention, National Center for Environmental Health, Division of Laboratory Sciences, Atlanta, Georgia, United States of America
⨯
Jianlong Lou,

Affiliation Department of Anesthesia and Pharmaceutical Chemistry, University of California at San Francisco, San Francisco General Hospital, San Francisco, California, United States of America
⨯
Consuelo Garcia-Rodriguez,

Affiliation Department of Anesthesia and Pharmaceutical Chemistry, University of California at San Francisco, San Francisco General Hospital, San Francisco, California, United States of America
⨯
Isin N. Geren,

Affiliation Department of Anesthesia and Pharmaceutical Chemistry, University of California at San Francisco, San Francisco General Hospital, San Francisco, California, United States of America
⨯
Theresa J. Smith,

Affiliation Integrated Toxicology, United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Ft. Detrick, Maryland, United States of America
⨯
Hercules Moura,

Affiliation Centers for Disease Control and Prevention, National Center for Environmental Health, Division of Laboratory Sciences, Atlanta, Georgia, United States of America
⨯
James D. Marks,

Affiliation Department of Anesthesia and Pharmaceutical Chemistry, University of California at San Francisco, San Francisco General Hospital, San Francisco, California, United States of America
⨯
Leonard A. Smith,

Affiliation Integrated Toxicology, United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Ft. Detrick, Maryland, United States of America
⨯
James L. Pirkle,

Affiliation Centers for Disease Control and Prevention, National Center for Environmental Health, Division of Laboratory Sciences, Atlanta, Georgia, United States of America
⨯
John R. Barr

* E-mail: jbarr@cdc.gov

Affiliation Centers for Disease Control and Prevention, National Center for Environmental Health, Division of Laboratory Sciences, Atlanta, Georgia, United States of America
⨯

Extraction and Inhibition of Enzymatic Activity of Botulinum Neurotoxins/A1, /A2, and /A3 by a Panel of Monoclonal Anti-BoNT/A Antibodies

Suzanne R. Kalb,
Jianlong Lou,
Consuelo Garcia-Rodriguez,
Isin N. Geren,
Theresa J. Smith,
Hercules Moura,
James D. Marks,
Leonard A. Smith,
James L. Pirkle,
John R. Barr

Published: April 28, 2009
https://doi.org/10.1371/journal.pone.0005355

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Toxins
Is the Subject Area "Toxins" applicable to this article?

Thanks for your feedback.
Botulinum toxin
Is the Subject Area "Botulinum toxin" applicable to this article?

Thanks for your feedback.
Neurotoxins
Is the Subject Area "Neurotoxins" applicable to this article?

Thanks for your feedback.
Botulism
Is the Subject Area "Botulism" applicable to this article?

Thanks for your feedback.
Cross reactivity
Is the Subject Area "Cross reactivity" applicable to this article?

Thanks for your feedback.
Monoclonal antibodies
Is the Subject Area "Monoclonal antibodies" applicable to this article?

Thanks for your feedback.
Phosphates
Is the Subject Area "Phosphates" applicable to this article?

Thanks for your feedback.
Recombination reactions
Is the Subject Area "Recombination reactions" applicable to this article?

Thanks for your feedback.