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Open Access
Peer-reviewed
Research Article
Hypoxia Induces Dilated Cardiomyopathy in the Chick Embryo: Mechanism, Intervention, and Long-Term Consequences
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Andrei Tintu ,
Contributed equally to this work with: Andrei Tintu, Ellen Rouwet, Stefan Verlohren, Joep Brinkmann
Affiliations Laboratory for Angiogenesis and Cardiovascular Pathology, Max-Delbrueck-Center for Molecular Medicine, Berlin, Germany, Department of Surgery, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, the Netherlands
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Ellen Rouwet ,
Contributed equally to this work with: Andrei Tintu, Ellen Rouwet, Stefan Verlohren, Joep Brinkmann
Affiliation Department of Vascular Surgery, Erasmus University Medical Center, Rotterdam, the Netherlands
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Stefan Verlohren ,
Contributed equally to this work with: Andrei Tintu, Ellen Rouwet, Stefan Verlohren, Joep Brinkmann
Affiliations Laboratory for Angiogenesis and Cardiovascular Pathology, Max-Delbrueck-Center for Molecular Medicine, Berlin, Germany, Department of Obstetrics, Charité University Medicine, Berlin, Germany
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Joep Brinkmann ,
Contributed equally to this work with: Andrei Tintu, Ellen Rouwet, Stefan Verlohren, Joep Brinkmann
Affiliation Laboratory for Angiogenesis and Cardiovascular Pathology, Max-Delbrueck-Center for Molecular Medicine, Berlin, Germany
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Shakil Ahmad,
Affiliation Department of Reproductive & Vascular Biology, Centre for Cardiovascular Sciences, Institute for Biomedical Research, University of Birmingham, Birmingham, United Kingdom
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Fatima Crispi,
Affiliation Department of Maternal-Fetal Medicine, Hospital Clinic, University of Barcelona, Barcelona, Spain
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Marc van Bilsen,
Affiliation Department of Physiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, the Netherlands
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Peter Carmeliet,
Affiliation Center of Transgene Technology and Gene Therapy, University of Leuven, Leuven, Belgium
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Anne Cathrine Staff,
Affiliation Department of Obstetrics and Gynecology, Ulleval University Hospital, Oslo, Norway
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Marc Tjwa,
Affiliation Institute of Cardiovascular Regeneration, Centre for Molecular Medicine, University of Frankfurt, Frankfurt, Germany
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Irene Cetin,
Affiliation Institute of Obstetrics and Gynecology, IRCCS Foundation Policlinico, Mangiagalli & Regina Elena, University of Milan, Milan, Italy
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Eduard Gratacos,
Affiliation Department of Maternal-Fetal Medicine, Hospital Clinic, University of Barcelona, Barcelona, Spain
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Edgar Hernandez-Andrade,
Affiliation Department of Maternal-Fetal Medicine, Hospital Clinic, University of Barcelona, Barcelona, Spain
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Leo Hofstra,
Affiliation Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, the Netherlands
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Michael Jacobs,
Affiliation Department of Surgery, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, the Netherlands
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Wouter H. Lamers,
Affiliation Department of Embryology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, the Netherlands
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Ingo Morano,
Affiliation Research Group Molecular Muscle Physiology, Max-Delbrueck-Center for Molecular Medicine, Berlin, Germany
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Erdal Safak,
Affiliation Department of Cardiology, Franz Volhard Clinic, Helios Clinic Berlin-Buch, Charité University, Berlin, Germany
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Asif Ahmed,
Affiliation Department of Reproductive & Vascular Biology, Centre for Cardiovascular Sciences, Institute for Biomedical Research, University of Birmingham, Birmingham, United Kingdom
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Ferdinand le Noble
* E-mail: lenoble@mdc-berlin.de
Affiliation Laboratory for Angiogenesis and Cardiovascular Pathology, Max-Delbrueck-Center for Molecular Medicine, Berlin, Germany
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Hypoxia Induces Dilated Cardiomyopathy in the Chick Embryo: Mechanism, Intervention, and Long-Term Consequences
- Andrei Tintu,
- Ellen Rouwet,
- Stefan Verlohren,
- Joep Brinkmann,
- Shakil Ahmad,
- Fatima Crispi,
- Marc van Bilsen,
- Peter Carmeliet,
- Anne Cathrine Staff,
- Marc Tjwa
- Published: April 9, 2009
- https://doi.org/10.1371/journal.pone.0005155