A Central Role for Foxp3+ Regulatory T Cells in K-Ras-Driven Lung Tumorigenesis

Courtney A. Granville; Regan M. Memmott; Andria Balogh; Jacopo Mariotti; Shigeru Kawabata; Wei Han; Jaclyn LoPiccolo; Jason Foley; David J. Liewehr; Seth M. Steinberg; Daniel H. Fowler; M. Christine Hollander; Phillip A. Dennis

doi:10.1371/journal.pone.0005061

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Open Access

Peer-reviewed

Research Article

A Central Role for Foxp3+ Regulatory T Cells in K-Ras-Driven Lung Tumorigenesis

Courtney A. Granville ,

Contributed equally to this work with: Courtney A. Granville, Regan M. Memmott

Affiliation Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America
⨯
Regan M. Memmott ,

Contributed equally to this work with: Courtney A. Granville, Regan M. Memmott

Affiliation Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America
⨯
Andria Balogh,

Affiliation Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America
⨯
Jacopo Mariotti,

Affiliation Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America
⨯
Shigeru Kawabata,

Affiliation Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America
⨯
Wei Han,

Affiliation Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America
⨯
Jaclyn LoPiccolo,

Affiliation Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America
⨯
Jason Foley,

Affiliation Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America
⨯
David J. Liewehr,

Affiliation Biostatistics and Data Management Section, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America
⨯
Seth M. Steinberg,

Affiliation Biostatistics and Data Management Section, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America
⨯
Daniel H. Fowler,

Affiliation Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America
⨯
M. Christine Hollander,

Affiliation Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America
⨯
Phillip A. Dennis

* E-mail: pdennis@nih.gov

Affiliation Medical Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, United States of America
⨯

A Central Role for Foxp3+ Regulatory T Cells in K-Ras-Driven Lung Tumorigenesis

Courtney A. Granville,
Regan M. Memmott,
Andria Balogh,
Jacopo Mariotti,
Shigeru Kawabata,
Wei Han,
Jaclyn LoPiccolo,
Jason Foley,
David J. Liewehr,
Seth M. Steinberg

Published: March 30, 2009
https://doi.org/10.1371/journal.pone.0005061

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03 Apr 2009
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Lung and intrathoracic tumors
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Secondary lung tumors
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Regulatory T cells
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