A Novel Immune Evasion Strategy of Candida albicans: Proteolytic Cleavage of a Salivary Antimicrobial Peptide

Timothy F. Meiller; Bernhard Hube; Lydia Schild; Mark E. Shirtliff; Mark A. Scheper; Robert Winkler; Amy Ton; Mary Ann Jabra-Rizk

doi:10.1371/journal.pone.0005039

Loading metrics

Open Access

Peer-reviewed

Research Article

A Novel Immune Evasion Strategy of Candida albicans: Proteolytic Cleavage of a Salivary Antimicrobial Peptide

Timothy F. Meiller,

Affiliations Department of Oncology and Diagnostic Sciences, University of Maryland – Baltimore, Baltimore, Maryland, United States of America, Marlene and Stewart Greenbaum Cancer Center, University of Maryland Medical System, Baltimore, Maryland, United States of America
⨯
Bernhard Hube,

Affiliations Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology, Hans-Knoell-Institute (HKI), Jena, Germany, Friedrich Schiller University, Jena, Germany
⨯
Lydia Schild,

Affiliation Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology, Hans-Knoell-Institute (HKI), Jena, Germany
⨯
Mark E. Shirtliff,

Affiliations Department of Microbial Pathogenesis, Dental School, University of Maryland – Baltimore, Baltimore, Maryland, United States of America, Department of Microbiology and Immunology, School of Medicine, University of Maryland – Baltimore, Baltimore, Maryland, United States of America
⨯
Mark A. Scheper,

Affiliations Department of Oncology and Diagnostic Sciences, University of Maryland – Baltimore, Baltimore, Maryland, United States of America, Marlene and Stewart Greenbaum Cancer Center, University of Maryland Medical System, Baltimore, Maryland, United States of America
⨯
Robert Winkler,

Current address: Department of Biotechnology and Food Engineering, Tecnológico de Monterrey (ITESM), Monterrey, Nuevo León, Mexico

Affiliation Department of Biomolecular Chemistry, Leibniz Institute for Natural Product Research and Infection Biology, Hans-Knoell-Institute (HKI), Jena, Germany
⨯
Amy Ton,

Affiliation Department of Oncology and Diagnostic Sciences, University of Maryland – Baltimore, Baltimore, Maryland, United States of America
⨯
Mary Ann Jabra-Rizk

* E-mail: mrizk@umaryland.edu

Affiliations Department of Oncology and Diagnostic Sciences, University of Maryland – Baltimore, Baltimore, Maryland, United States of America, Department of Pathology, School of Medicine, University of Maryland – Baltimore, Baltimore, Maryland, United States of America
⨯

A Novel Immune Evasion Strategy of Candida albicans: Proteolytic Cleavage of a Salivary Antimicrobial Peptide

Timothy F. Meiller,
Bernhard Hube,
Lydia Schild,
Mark E. Shirtliff,
Mark A. Scheper,
Robert Winkler,
Amy Ton,
Mary Ann Jabra-Rizk

Published: April 7, 2009
https://doi.org/10.1371/journal.pone.0005039

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Candida albicans
Is the Subject Area "Candida albicans" applicable to this article?

Thanks for your feedback.
Proteases
Is the Subject Area "Proteases" applicable to this article?

Thanks for your feedback.
Candidiasis
Is the Subject Area "Candidiasis" applicable to this article?

Thanks for your feedback.
Proteolysis
Is the Subject Area "Proteolysis" applicable to this article?

Thanks for your feedback.
Opportunistic infections
Is the Subject Area "Opportunistic infections" applicable to this article?

Thanks for your feedback.
Caries
Is the Subject Area "Caries" applicable to this article?

Thanks for your feedback.
Opportunistic pathogens
Is the Subject Area "Opportunistic pathogens" applicable to this article?

Thanks for your feedback.
Fungal pathogens
Is the Subject Area "Fungal pathogens" applicable to this article?

Thanks for your feedback.