Genome-Wide Hypomethylation in Head and Neck Cancer Is More Pronounced in HPV-Negative Tumors and Is Associated with Genomic Instability

Kristy L. Richards; Baili Zhang; Keith A. Baggerly; Stefano Colella; James C. Lang; David E. Schuller; Ralf Krahe

doi:10.1371/journal.pone.0004941

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Peer-reviewed

Research Article

Genome-Wide Hypomethylation in Head and Neck Cancer Is More Pronounced in HPV-Negative Tumors and Is Associated with Genomic Instability

Kristy L. Richards,

Current address: Division of Hematology/Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina, United States of America

Affiliations Department of Genetics, University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America, Division of Cancer Medicine, University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America
⨯
Baili Zhang,

Affiliation Department of Genetics, University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America
⨯
Keith A. Baggerly,

Affiliations Department of Bioinformatics and Computational Biology, University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America, Graduate Program in Human and Molecular Genetics, University of Texas at Houston Graduate School in Biomedical Sciences, Houston, Texas, United States of America
⨯
Stefano Colella,

Current address: UMR 203 INRA INSA-Lyon BF2I, Biologie Fonctionnelle Insectes et Interactions, Bât. L. Pasteur, Villeurbanne, France

Affiliation Department of Genetics, University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America
⨯
James C. Lang,

Affiliation Molecular Biology and Cancer Genetics Programs, Ohio State University, Comprehensive Cancer Center, Columbus, Ohio, United States of America
⨯
David E. Schuller,

Affiliation Molecular Biology and Cancer Genetics Programs, Ohio State University, Comprehensive Cancer Center, Columbus, Ohio, United States of America
⨯
Ralf Krahe

* E-mail: rkrahe@mdanderson.org

Affiliations Department of Genetics, University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America, Department of Thoracic/Head and Neck Medical Oncology, University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America, Graduate Program in Human and Molecular Genetics, University of Texas at Houston Graduate School in Biomedical Sciences, Houston, Texas, United States of America, Graduate Program in Genes and Development, University of Texas at Houston Graduate School in Biomedical Sciences, Houston, Texas, United States of America
⨯

Genome-Wide Hypomethylation in Head and Neck Cancer Is More Pronounced in HPV-Negative Tumors and Is Associated with Genomic Instability

Kristy L. Richards,
Baili Zhang,
Keith A. Baggerly,
Stefano Colella,
James C. Lang,
David E. Schuller,
Ralf Krahe

Published: March 18, 2009
https://doi.org/10.1371/journal.pone.0004941

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DNA methylation
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Alu elements
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Methylation
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Head and neck cancers
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