Molecular Basis of Filamin A-FilGAP Interaction and Its Impairment in Congenital Disorders Associated with Filamin A Mutations

Fumihiko Nakamura; Outi Heikkinen; Olli T. Pentikäinen; Teresia M. Osborn; Karen E. Kasza; David A. Weitz; Olga Kupiainen; Perttu Permi; Ilkka Kilpeläinen; Jari Ylänne; John H. Hartwig; Thomas P. Stossel

doi:10.1371/journal.pone.0004928

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Open Access

Peer-reviewed

Research Article

Molecular Basis of Filamin A-FilGAP Interaction and Its Impairment in Congenital Disorders Associated with Filamin A Mutations

Fumihiko Nakamura ,

* E-mail: fnakamura@rics.bwh.harvard.edu

Affiliation Translational Medicine Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Outi Heikkinen,

Affiliation Laboratory of Organic Chemistry, Department of Chemistry, University of Helsinki, Helsinki, Finland
⨯
Olli T. Pentikäinen,

Affiliation Department of Biological and Environmental Science, University of Jyväskylä, Jyväskylä, Finland
⨯
Teresia M. Osborn,

Affiliation Translational Medicine Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Karen E. Kasza,

Affiliation Department of Physics & SEAS, Harvard University, Cambridge, Massachusetts, United States of America
⨯
David A. Weitz,

Affiliation Department of Physics & SEAS, Harvard University, Cambridge, Massachusetts, United States of America
⨯
Olga Kupiainen,

Affiliation Laboratory of Organic Chemistry, Department of Chemistry, University of Helsinki, Helsinki, Finland
⨯
Perttu Permi,

Affiliation Program in Structural Biology and Biophysics, Institute of Biotechnology, University of Helsinki, Helsinki, Finland
⨯
Ilkka Kilpeläinen,

Affiliation Laboratory of Organic Chemistry, Department of Chemistry, University of Helsinki, Helsinki, Finland
⨯
Jari Ylänne,

Affiliation Department of Biological and Environmental Science, University of Jyväskylä, Jyväskylä, Finland
⨯
John H. Hartwig,

Affiliation Translational Medicine Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Thomas P. Stossel

Affiliation Translational Medicine Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
⨯

Molecular Basis of Filamin A-FilGAP Interaction and Its Impairment in Congenital Disorders Associated with Filamin A Mutations

Fumihiko Nakamura,
Outi Heikkinen,
Olli T. Pentikäinen,
Teresia M. Osborn,
Karen E. Kasza,
David A. Weitz,
Olga Kupiainen,
Perttu Permi,
Ilkka Kilpeläinen,
Jari Ylänne

Published: March 18, 2009
https://doi.org/10.1371/journal.pone.0004928

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