Two-Dimensional Electrophoresis of Tau Mutants Reveals Specific Phosphorylation Pattern Likely Linked to Early Tau Conformational Changes

Alexis Bretteville; Kunie Ando; Antoine Ghestem; Anne Loyens; Séverine Bégard; Jean-Claude Beauvillain; Nicolas Sergeant; Malika Hamdane; Luc Buée

doi:10.1371/journal.pone.0004843

Loading metrics

Open Access

Peer-reviewed

Research Article

Two-Dimensional Electrophoresis of Tau Mutants Reveals Specific Phosphorylation Pattern Likely Linked to Early Tau Conformational Changes

Alexis Bretteville,

Affiliations Inserm, U837, Place de Verdun, Lille, France, Université Lille 2, Faculté de Médecine, Institut de Médecine Prédictive et Recherche Thérapeutique, Jean-Pierre Aubert Research Centre, Lille, France
⨯
Kunie Ando,

Affiliations Inserm, U837, Place de Verdun, Lille, France, Université Lille 2, Faculté de Médecine, Institut de Médecine Prédictive et Recherche Thérapeutique, Jean-Pierre Aubert Research Centre, Lille, France
⨯
Antoine Ghestem,

Affiliations Inserm, U837, Place de Verdun, Lille, France, Université Lille 2, Faculté de Médecine, Institut de Médecine Prédictive et Recherche Thérapeutique, Jean-Pierre Aubert Research Centre, Lille, France
⨯
Anne Loyens,

Affiliations Inserm, U837, Place de Verdun, Lille, France, Université Lille 2, Faculté de Médecine, Institut de Médecine Prédictive et Recherche Thérapeutique, Jean-Pierre Aubert Research Centre, Lille, France
⨯
Séverine Bégard,

Affiliations Inserm, U837, Place de Verdun, Lille, France, Université Lille 2, Faculté de Médecine, Institut de Médecine Prédictive et Recherche Thérapeutique, Jean-Pierre Aubert Research Centre, Lille, France
⨯
Jean-Claude Beauvillain,

Affiliations Inserm, U837, Place de Verdun, Lille, France, Université Lille 2, Faculté de Médecine, Institut de Médecine Prédictive et Recherche Thérapeutique, Jean-Pierre Aubert Research Centre, Lille, France
⨯
Nicolas Sergeant,

Affiliations Inserm, U837, Place de Verdun, Lille, France, Université Lille 2, Faculté de Médecine, Institut de Médecine Prédictive et Recherche Thérapeutique, Jean-Pierre Aubert Research Centre, Lille, France
⨯
Malika Hamdane ,

Contributed equally to this work with: Malika Hamdane, Luc Buée

Affiliations Inserm, U837, Place de Verdun, Lille, France, Université Lille 2, Faculté de Médecine, Institut de Médecine Prédictive et Recherche Thérapeutique, Jean-Pierre Aubert Research Centre, Lille, France
⨯
Luc Buée

Contributed equally to this work with: Malika Hamdane, Luc Buée

* E-mail: luc.buee@inserm.fr

Affiliations Inserm, U837, Place de Verdun, Lille, France, Université Lille 2, Faculté de Médecine, Institut de Médecine Prédictive et Recherche Thérapeutique, Jean-Pierre Aubert Research Centre, Lille, France
⨯

Two-Dimensional Electrophoresis of Tau Mutants Reveals Specific Phosphorylation Pattern Likely Linked to Early Tau Conformational Changes

Alexis Bretteville,
Kunie Ando,
Antoine Ghestem,
Anne Loyens,
Séverine Bégard,
Jean-Claude Beauvillain,
Nicolas Sergeant,
Malika Hamdane,
Luc Buée

Published: March 17, 2009
https://doi.org/10.1371/journal.pone.0004843

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Phosphorylation
Is the Subject Area "Phosphorylation" applicable to this article?

Thanks for your feedback.
Mouse models
Is the Subject Area "Mouse models" applicable to this article?

Thanks for your feedback.
Immunoblotting
Is the Subject Area "Immunoblotting" applicable to this article?

Thanks for your feedback.
Tetracyclines
Is the Subject Area "Tetracyclines" applicable to this article?

Thanks for your feedback.
Molecular pathology
Is the Subject Area "Molecular pathology" applicable to this article?

Thanks for your feedback.
Cell differentiation
Is the Subject Area "Cell differentiation" applicable to this article?

Thanks for your feedback.
Cytopathology
Is the Subject Area "Cytopathology" applicable to this article?

Thanks for your feedback.
Alzheimer's disease
Is the Subject Area "Alzheimer's disease" applicable to this article?

Thanks for your feedback.