Preliminary Evidence for Cell Membrane Amelioration in Children with Cystic Fibrosis by 5-MTHF and Vitamin B12 Supplementation: A Single Arm Trial

Cinzia Scambi; Lucia De Franceschi; Patrizia Guarini; Fabio Poli; Angela Siciliano; Patrizia Pattini; Andrea Biondani; Valentina La Verde; Oscar Bortolami; Francesco Turrini; Franco Carta; Ciro D'Orazio; Baroukh M. Assael; Giovanni Faccini; Lisa M. Bambara

doi:10.1371/journal.pone.0004782

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Open Access

Peer-reviewed

Research Article

Preliminary Evidence for Cell Membrane Amelioration in Children with Cystic Fibrosis by 5-MTHF and Vitamin B12 Supplementation: A Single Arm Trial

Cinzia Scambi ,

* E-mail: cinzia.scambi@medicina.univr.it

Affiliation Department of Clinical and Experimental Medicine, Section of Rheumatology & Internal Medicine, University of Verona, Verona, Italy
⨯
Lucia De Franceschi,

Affiliation Department of Clinical and Experimental Medicine, Section of Rheumatology & Internal Medicine, University of Verona, Verona, Italy
⨯
Patrizia Guarini,

Affiliation Department of Clinical and Experimental Medicine, Section of Rheumatology & Internal Medicine, University of Verona, Verona, Italy
⨯
Fabio Poli,

Affiliation Department of Clinical and Experimental Medicine, Section of Rheumatology & Internal Medicine, University of Verona, Verona, Italy
⨯
Angela Siciliano,

Affiliation Department of Clinical and Experimental Medicine, Section of Rheumatology & Internal Medicine, University of Verona, Verona, Italy
⨯
Patrizia Pattini,

Affiliation Department of Clinical and Experimental Medicine, Section of Rheumatology & Internal Medicine, University of Verona, Verona, Italy
⨯
Andrea Biondani,

Affiliation Department of Clinical and Experimental Medicine, Section of Rheumatology & Internal Medicine, University of Verona, Verona, Italy
⨯
Valentina La Verde,

Affiliation Department of Clinical and Experimental Medicine, Section of Rheumatology & Internal Medicine, University of Verona, Verona, Italy
⨯
Oscar Bortolami,

Affiliation Department of Medicine and Public Health, Unit of Epidemiology and Medical Statistics, University of Verona, Verona, Italy
⨯
Francesco Turrini,

Affiliation Department of Genetic, Biological and Medical Chemistry, Section of Medical Chemistry, University of Torino, Torino, Italy
⨯
Franco Carta,

Affiliation Nurex, Sassari, Italy
⨯
Ciro D'Orazio,

Affiliation Center for Cystic Fibrosis Care, Hospital of Verona, Verona, Italy
⨯
Baroukh M. Assael,

Affiliation Center for Cystic Fibrosis Care, Hospital of Verona, Verona, Italy
⨯
Giovanni Faccini,

Affiliation Department of Biomedical and Morphological Science, Section of Clinical Chemistry, University of Verona, Verona, Italy
⨯
Lisa M. Bambara

Affiliation Department of Clinical and Experimental Medicine, Section of Rheumatology & Internal Medicine, University of Verona, Verona, Italy
⨯

Preliminary Evidence for Cell Membrane Amelioration in Children with Cystic Fibrosis by 5-MTHF and Vitamin B12 Supplementation: A Single Arm Trial

Cinzia Scambi,
Lucia De Franceschi,
Patrizia Guarini,
Fabio Poli,
Angela Siciliano,
Patrizia Pattini,
Andrea Biondani,
Valentina La Verde,
Oscar Bortolami,
Francesco Turrini

Published: March 11, 2009
https://doi.org/10.1371/journal.pone.0004782

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Cystic fibrosis
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Cell membranes
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Red blood cells
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Cobalamins
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Membrane proteins
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Fatty acids
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Blood plasma
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Oxidative damage
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