TRAF6 Is Required for Generation of the B-1a B Cell Compartment as well as T Cell-Dependent and -Independent Humoral Immune Responses

Takashi Kobayashi; Tae Soo Kim; Anand Jacob; Matthew C. Walsh; Yuho Kadono; Ezequiel Fuentes-Pananá; Tomoko Yoshioka; Akihiko Yoshimura; Masahiro Yamamoto; Tsuneyasu Kaisho; Shizuo Akira; John G. Monroe; Yongwon Choi

doi:10.1371/journal.pone.0004736

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Open Access

Peer-reviewed

Research Article

TRAF6 Is Required for Generation of the B-1a B Cell Compartment as well as T Cell-Dependent and -Independent Humoral Immune Responses

Takashi Kobayashi ,

* E-mail: takashik@bioreg.kyushu-u.ac.jp (TK); ychoi3@mail.med.upenn.edu (YC)

Affiliation Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
⨯
Tae Soo Kim,

Affiliation Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Anand Jacob,

Affiliation Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Matthew C. Walsh,

Affiliation Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Yuho Kadono,

Affiliation Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Ezequiel Fuentes-Pananá,

Affiliation Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Tomoko Yoshioka,

Affiliation Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
⨯
Akihiko Yoshimura,

Affiliation Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan
⨯
Masahiro Yamamoto,

Affiliation Department of Host Defense, World Premier International Immunology Frontier Research Center, and the Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
⨯
Tsuneyasu Kaisho,

Affiliation Department of Host Defense, World Premier International Immunology Frontier Research Center, and the Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
⨯
Shizuo Akira,

Affiliation Department of Host Defense, World Premier International Immunology Frontier Research Center, and the Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
⨯
John G. Monroe,

Affiliation Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Yongwon Choi

* E-mail: takashik@bioreg.kyushu-u.ac.jp (TK); ychoi3@mail.med.upenn.edu (YC)

Affiliation Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯

TRAF6 Is Required for Generation of the B-1a B Cell Compartment as well as T Cell-Dependent and -Independent Humoral Immune Responses

Takashi Kobayashi,
Tae Soo Kim,
Anand Jacob,
Matthew C. Walsh,
Yuho Kadono,
Ezequiel Fuentes-Pananá,
Tomoko Yoshioka,
Akihiko Yoshimura,
Masahiro Yamamoto,
Tsuneyasu Kaisho

Published: March 9, 2009
https://doi.org/10.1371/journal.pone.0004736

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