Mitogen Activated Protein Kinase Activated Protein Kinase 2 Regulates Actin Polymerization and Vascular Leak in Ventilator Associated Lung Injury

Mahendra Damarla; Emile Hasan; Adel Boueiz; Anne Le; Hyun Hae Pae; Calypso Montouchet; Todd Kolb; Tiffany Simms; Allen Myers; Usamah S. Kayyali; Matthias Gaestel; Xinqi Peng; Sekhar P. Reddy; Rachel Damico; Paul M. Hassoun

doi:10.1371/journal.pone.0004600

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Peer-reviewed

Research Article

Mitogen Activated Protein Kinase Activated Protein Kinase 2 Regulates Actin Polymerization and Vascular Leak in Ventilator Associated Lung Injury

Mahendra Damarla,

Affiliation Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Emile Hasan,

Affiliation Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Adel Boueiz,

Affiliation Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Anne Le,

Affiliation Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Hyun Hae Pae,

Affiliation Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Calypso Montouchet,

Affiliation Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Todd Kolb,

Affiliation Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Tiffany Simms,

Affiliation Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Allen Myers,

Affiliation Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Usamah S. Kayyali,

Affiliation Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts, United States of America
⨯
Matthias Gaestel,

Affiliation Department of Biochemistry, Medical School of Hannover, Hannover, Germany
⨯
Xinqi Peng,

Affiliation Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Sekhar P. Reddy,

Affiliation Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
⨯
Rachel Damico,

Affiliation Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Paul M. Hassoun

* E-mail: phassoun@jhmi.edu

Affiliation Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯

Mitogen Activated Protein Kinase Activated Protein Kinase 2 Regulates Actin Polymerization and Vascular Leak in Ventilator Associated Lung Injury

Mahendra Damarla,
Emile Hasan,
Adel Boueiz,
Anne Le,
Hyun Hae Pae,
Calypso Montouchet,
Todd Kolb,
Tiffany Simms,
Allen Myers,
Usamah S. Kayyali

Published: February 25, 2009
https://doi.org/10.1371/journal.pone.0004600

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Vascular permeability
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Actin polymerization
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Tidal volume
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Breathing
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Actins
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