Disruption of Growth Hormone Receptor Prevents Calorie Restriction from Improving Insulin Action and Longevity

Michael S. Bonkowski; Fernando P. Dominici; Oge Arum; Juliana S. Rocha; Khalid A. Al Regaiey; Reyhan Westbrook; Adam Spong; Jacob Panici; Michal M. Masternak; John J. Kopchick; Andrzej Bartke

doi:10.1371/journal.pone.0004567

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Open Access

Peer-reviewed

Research Article

Disruption of Growth Hormone Receptor Prevents Calorie Restriction from Improving Insulin Action and Longevity

Michael S. Bonkowski,

Affiliations Department of Internal Medicine – Geriatrics Research, Southern Illinois University School of Medicine, Springfield, Illinois, United States of America, Department of Pharmacology, and Physiology, Southern Illinois University School of Medicine, Springfield, Illinois, United States of America
⨯
Fernando P. Dominici,

Affiliation Instituto de Química y Fisicoquímica Biológicas (IQUIFIB), Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina
⨯
Oge Arum,

Affiliation Department of Internal Medicine – Geriatrics Research, Southern Illinois University School of Medicine, Springfield, Illinois, United States of America
⨯
Juliana S. Rocha,

Affiliations Department of Internal Medicine – Geriatrics Research, Southern Illinois University School of Medicine, Springfield, Illinois, United States of America, Department of Morphology, Laboratory of Cellular Biology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil
⨯
Khalid A. Al Regaiey,

Affiliations Department of Internal Medicine – Geriatrics Research, Southern Illinois University School of Medicine, Springfield, Illinois, United States of America, Department of Physiology, College of Medicine, King Saud University, Riyadh, Saudi Arabia
⨯
Reyhan Westbrook,

Affiliation Department of Internal Medicine – Geriatrics Research, Southern Illinois University School of Medicine, Springfield, Illinois, United States of America
⨯
Adam Spong,

Affiliation Department of Internal Medicine – Geriatrics Research, Southern Illinois University School of Medicine, Springfield, Illinois, United States of America
⨯
Jacob Panici,

Affiliation Department of Internal Medicine – Geriatrics Research, Southern Illinois University School of Medicine, Springfield, Illinois, United States of America
⨯
Michal M. Masternak,

Affiliation Department of Internal Medicine – Geriatrics Research, Southern Illinois University School of Medicine, Springfield, Illinois, United States of America
⨯
John J. Kopchick,

Affiliation Department of Biomedical Sciences, Edison Biotechnology Institute, Ohio University, Athens, Ohio, United States of America
⨯
Andrzej Bartke

* E-mail: abartke@siumed.edu

Affiliations Department of Internal Medicine – Geriatrics Research, Southern Illinois University School of Medicine, Springfield, Illinois, United States of America, Department of Pharmacology, and Physiology, Southern Illinois University School of Medicine, Springfield, Illinois, United States of America
⨯

Disruption of Growth Hormone Receptor Prevents Calorie Restriction from Improving Insulin Action and Longevity

Michael S. Bonkowski,
Fernando P. Dominici,
Oge Arum,
Juliana S. Rocha,
Khalid A. Al Regaiey,
Reyhan Westbrook,
Adam Spong,
Jacob Panici,
Michal M. Masternak,
John J. Kopchick

Published: February 23, 2009
https://doi.org/10.1371/journal.pone.0004567

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Muscle proteins
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