Probiotics Prevent Intestinal Barrier Dysfunction in Acute Pancreatitis in Rats via Induction of Ileal Mucosal Glutathione Biosynthesis

Femke Lutgendorff; Rian M. Nijmeijer; Per A. Sandström; Lena M. Trulsson; Karl-Eric Magnusson; Harro M. Timmerman; L. Paul van Minnen; Ger T. Rijkers; Hein G. Gooszen; Louis M. A. Akkermans; Johan D. Söderholm

doi:10.1371/journal.pone.0004512

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Open Access

Peer-reviewed

Research Article

Probiotics Prevent Intestinal Barrier Dysfunction in Acute Pancreatitis in Rats via Induction of Ileal Mucosal Glutathione Biosynthesis

Femke Lutgendorff,

Affiliations Department of Clinical and Experimental Medicine, Division of Surgery, Linköping University, Linköping, Sweden, Gastrointestinal Research Unit, Department of Surgery, University Medical Center, Utrecht, the Netherlands
⨯
Rian M. Nijmeijer,

Affiliation Gastrointestinal Research Unit, Department of Surgery, University Medical Center, Utrecht, the Netherlands
⨯
Per A. Sandström,

Affiliation Department of Clinical and Experimental Medicine, Division of Surgery, Linköping University, Linköping, Sweden
⨯
Lena M. Trulsson,

Affiliation Department of Clinical and Experimental Medicine, Division of Surgery, Linköping University, Linköping, Sweden
⨯
Karl-Eric Magnusson,

Affiliation Department of Clinical and Experimental Medicine, Division of Medical Microbiology, Linköping University, Linköping, Sweden
⨯
Harro M. Timmerman,

Affiliation Gastrointestinal Research Unit, Department of Surgery, University Medical Center, Utrecht, the Netherlands
⨯
L. Paul van Minnen,

Affiliation Gastrointestinal Research Unit, Department of Surgery, University Medical Center, Utrecht, the Netherlands
⨯
Ger T. Rijkers,

Affiliation Gastrointestinal Research Unit, Department of Surgery, University Medical Center, Utrecht, the Netherlands
⨯
Hein G. Gooszen,

Affiliation Gastrointestinal Research Unit, Department of Surgery, University Medical Center, Utrecht, the Netherlands
⨯
Louis M. A. Akkermans,

Affiliation Gastrointestinal Research Unit, Department of Surgery, University Medical Center, Utrecht, the Netherlands
⨯
Johan D. Söderholm

* E-mail: johan.d.soderholm@liu.se

Affiliation Department of Clinical and Experimental Medicine, Division of Surgery, Linköping University, Linköping, Sweden
⨯

Probiotics Prevent Intestinal Barrier Dysfunction in Acute Pancreatitis in Rats via Induction of Ileal Mucosal Glutathione Biosynthesis

Femke Lutgendorff,
Rian M. Nijmeijer,
Per A. Sandström,
Lena M. Trulsson,
Karl-Eric Magnusson,
Harro M. Timmerman,
L. Paul van Minnen,
Ger T. Rijkers,
Hein G. Gooszen,
Louis M. A. Akkermans

Published: February 18, 2009
https://doi.org/10.1371/journal.pone.0004512

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