Depletion of Kinesin 5B Affects Lysosomal Distribution and Stability and Induces Peri-Nuclear Accumulation of Autophagosomes in Cancer Cells

Carla M. P. Cardoso; Line Groth-Pedersen; Maria Høyer-Hansen; Thomas Kirkegaard; Elizabeth Corcelle; Jens S. Andersen; Marja Jäättelä; Jesper Nylandsted

doi:10.1371/journal.pone.0004424

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Peer-reviewed

Research Article

Depletion of Kinesin 5B Affects Lysosomal Distribution and Stability and Induces Peri-Nuclear Accumulation of Autophagosomes in Cancer Cells

Carla M. P. Cardoso,

Affiliation Center for Neuroscience and Cell Biology, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
⨯
Line Groth-Pedersen,

Affiliation Apoptosis Department and Centre for Genotoxic Stress Research, Institute of Cancer Biology, Danish Cancer Society, Copenhagen, Denmark
⨯
Maria Høyer-Hansen,

Affiliation Apoptosis Department and Centre for Genotoxic Stress Research, Institute of Cancer Biology, Danish Cancer Society, Copenhagen, Denmark
⨯
Thomas Kirkegaard,

Affiliation Apoptosis Department and Centre for Genotoxic Stress Research, Institute of Cancer Biology, Danish Cancer Society, Copenhagen, Denmark
⨯
Elizabeth Corcelle,

Affiliations Center for Neuroscience and Cell Biology, Faculty of Medicine, University of Coimbra, Coimbra, Portugal, Apoptosis Department and Centre for Genotoxic Stress Research, Institute of Cancer Biology, Danish Cancer Society, Copenhagen, Denmark, Centre for Experimental Bioinformatics (CEBI), University of Southern Denmark, Odense, Denmark
⨯
Jens S. Andersen,

Affiliation Centre for Experimental Bioinformatics (CEBI), University of Southern Denmark, Odense, Denmark
⨯
Marja Jäättelä ,

Contributed equally to this work with: Marja Jäättelä, Jesper Nylandsted

* E-mail: mj@cancer.dk (MJ); jnl@cancer.dk (JN)

Affiliation Apoptosis Department and Centre for Genotoxic Stress Research, Institute of Cancer Biology, Danish Cancer Society, Copenhagen, Denmark
⨯
Jesper Nylandsted

Contributed equally to this work with: Marja Jäättelä, Jesper Nylandsted

* E-mail: mj@cancer.dk (MJ); jnl@cancer.dk (JN)

Affiliation Apoptosis Department and Centre for Genotoxic Stress Research, Institute of Cancer Biology, Danish Cancer Society, Copenhagen, Denmark
⨯

Depletion of Kinesin 5B Affects Lysosomal Distribution and Stability and Induces Peri-Nuclear Accumulation of Autophagosomes in Cancer Cells

Carla M. P. Cardoso,
Line Groth-Pedersen,
Maria Høyer-Hansen,
Thomas Kirkegaard,
Elizabeth Corcelle,
Jens S. Andersen,
Marja Jäättelä,
Jesper Nylandsted

Published: February 10, 2009
https://doi.org/10.1371/journal.pone.0004424

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