Graded Smad2/3 Activation Is Converted Directly into Levels of Target Gene Expression in Embryonic Stem Cells

Open Access

Peer-reviewed

Research Article

Marcela Guzman-Ayala ,

Contributed equally to this work with: Marcela Guzman-Ayala, Kian Leong Lee

Affiliation Mammalian Neurogenesis, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom
⨯
Kian Leong Lee ,

Contributed equally to this work with: Marcela Guzman-Ayala, Kian Leong Lee

Affiliation Mammalian Neurogenesis, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom
⨯
Konstantinos J. Mavrakis,

Affiliation Mammalian Neurogenesis, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom
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Paraskevi Goggolidou,

Affiliation Mammalian Genetics Unit, MRC, Harwell, United Kingdom
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Dominic P. Norris,

Affiliation Mammalian Genetics Unit, MRC, Harwell, United Kingdom
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Vasso Episkopou

* E-mail: vepiskop@csc.mrc.ac.uk

Affiliation Mammalian Neurogenesis, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom
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Protein synthesis
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SMAD signaling
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Gene expression
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DNA transcription
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Gene regulation
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Microarrays
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Phosphorylation
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Morphogens
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