Overexpression of Myocilin in the Drosophila Eye Activates the Unfolded Protein Response: Implications for Glaucoma

Mary Anna Carbone; Julien F. Ayroles; Akihiko Yamamoto; Tatiana V. Morozova; Steven A. West; Michael M. Magwire; Trudy F. C. Mackay; Robert R. H. Anholt

doi:10.1371/journal.pone.0004216

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Peer-reviewed

Research Article

Overexpression of Myocilin in the Drosophila Eye Activates the Unfolded Protein Response: Implications for Glaucoma

Mary Anna Carbone,

Affiliations Department of Genetics, North Carolina State University, Raleigh, North Carolina, United States of America, W. M. Keck Center for Behavioral Biology, North Carolina State University, Raleigh, North Carolina, United States of America
⨯
Julien F. Ayroles,

Affiliations Department of Genetics, North Carolina State University, Raleigh, North Carolina, United States of America, W. M. Keck Center for Behavioral Biology, North Carolina State University, Raleigh, North Carolina, United States of America
⨯
Akihiko Yamamoto,

Affiliations Department of Genetics, North Carolina State University, Raleigh, North Carolina, United States of America, Department of Zoology, North Carolina State University, Raleigh, North Carolina, United States of America, W. M. Keck Center for Behavioral Biology, North Carolina State University, Raleigh, North Carolina, United States of America
⨯
Tatiana V. Morozova,

Affiliations Department of Zoology, North Carolina State University, Raleigh, North Carolina, United States of America, W. M. Keck Center for Behavioral Biology, North Carolina State University, Raleigh, North Carolina, United States of America
⨯
Steven A. West,

Affiliations Department of Zoology, North Carolina State University, Raleigh, North Carolina, United States of America, W. M. Keck Center for Behavioral Biology, North Carolina State University, Raleigh, North Carolina, United States of America
⨯
Michael M. Magwire,

Current address: Institute of Evolutionary Biology, University of Edinburgh, Edinburgh, United Kingdom

Affiliations Department of Genetics, North Carolina State University, Raleigh, North Carolina, United States of America, W. M. Keck Center for Behavioral Biology, North Carolina State University, Raleigh, North Carolina, United States of America
⨯
Trudy F. C. Mackay,

Affiliations Department of Genetics, North Carolina State University, Raleigh, North Carolina, United States of America, W. M. Keck Center for Behavioral Biology, North Carolina State University, Raleigh, North Carolina, United States of America
⨯
Robert R. H. Anholt

* E-mail: anholt@unity.ncsu.edu

Affiliations Department of Zoology, North Carolina State University, Raleigh, North Carolina, United States of America, W. M. Keck Center for Behavioral Biology, North Carolina State University, Raleigh, North Carolina, United States of America
⨯

Overexpression of Myocilin in the Drosophila Eye Activates the Unfolded Protein Response: Implications for Glaucoma

Mary Anna Carbone,
Julien F. Ayroles,
Akihiko Yamamoto,
Tatiana V. Morozova,
Steven A. West,
Michael M. Magwire,
Trudy F. C. Mackay,
Robert R. H. Anholt

Published: January 16, 2009
https://doi.org/10.1371/journal.pone.0004216

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Glaucoma
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Drosophila melanogaster
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Eyes
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Gene expression
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Trabecular meshwork
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Ophthalmology
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Gene regulation
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Motor proteins
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