Morphine Exacerbates HIV-1 Tat-Induced Cytokine Production in Astrocytes through Convergent Effects on [Ca2+]i, NF-κB Trafficking and Transcription

Nazira El-Hage; Annadora J. Bruce-Keller; Tatiana Yakovleva; Igor Bazov; Georgy Bakalkin; Pamela E. Knapp; Kurt F. Hauser

doi:10.1371/journal.pone.0004093

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Peer-reviewed

Research Article

Morphine Exacerbates HIV-1 Tat-Induced Cytokine Production in Astrocytes through Convergent Effects on [Ca²⁺]_i, NF-κB Trafficking and Transcription

Nazira El-Hage ,

* E-mail: nelhage@vcu.edu

Affiliation Department of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, Richmond, Virginia, United States of America
⨯
Annadora J. Bruce-Keller,

Affiliation Division of Basic Research, Pennington Biomedical Research Center/Louisiana State University, Baton Rouge, Louisiana, United States of America
⨯
Tatiana Yakovleva,

Affiliation The Division of Biological Research on Drug Dependence, Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden
⨯
Igor Bazov,

Affiliation The Division of Biological Research on Drug Dependence, Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden
⨯
Georgy Bakalkin,

Affiliation The Division of Biological Research on Drug Dependence, Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden
⨯
Pamela E. Knapp,

Affiliations Department of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, Richmond, Virginia, United States of America, Department of Anatomy and Neurobiology, Virginia Commonwealth University School of Medicine, Richmond, Virginia, United States of America, Institute for Drug and Alcohol Studies, Virginia Commonwealth University, Richmond, Virginia, United States of America
⨯
Kurt F. Hauser

Affiliations Department of Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, Richmond, Virginia, United States of America, Institute for Drug and Alcohol Studies, Virginia Commonwealth University, Richmond, Virginia, United States of America
⨯

Morphine Exacerbates HIV-1 Tat-Induced Cytokine Production in Astrocytes through Convergent Effects on [Ca²⁺]_i, NF-κB Trafficking and Transcription

Nazira El-Hage,
Annadora J. Bruce-Keller,
Tatiana Yakovleva,
Igor Bazov,
Georgy Bakalkin,
Pamela E. Knapp,
Kurt F. Hauser

Published: December 31, 2008
https://doi.org/10.1371/journal.pone.0004093

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