Analysis of STAT1 Activation by Six FGFR3 Mutants Associated with Skeletal Dysplasia Undermines Dominant Role of STAT1 in FGFR3 Signaling in Cartilage

Pavel Krejci; Lisa Salazar; Tamara A. Kashiwada; Katarina Chlebova; Alena Salasova; Leslie Michels Thompson; Vitezslav Bryja; Alois Kozubik; William R. Wilcox

doi:10.1371/journal.pone.0003961

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Peer-reviewed

Research Article

Analysis of STAT1 Activation by Six FGFR3 Mutants Associated with Skeletal Dysplasia Undermines Dominant Role of STAT1 in FGFR3 Signaling in Cartilage

Pavel Krejci ,

* E-mail: pavel.krejci@cshs.org

Affiliations Department of Animal Physiology and Immunology, Institute of Experimental Biology, Masaryk University, Brno, Czech Republic, Department of Cytokinetics, Institute of Biophysics ASCR, Brno, Czech Republic, Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America
⨯
Lisa Salazar,

Affiliation Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, California, United States of America
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Tamara A. Kashiwada,

Affiliation Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, California, United States of America
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Katarina Chlebova,

Affiliation Department of Animal Physiology and Immunology, Institute of Experimental Biology, Masaryk University, Brno, Czech Republic
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Alena Salasova,

Affiliation Department of Animal Physiology and Immunology, Institute of Experimental Biology, Masaryk University, Brno, Czech Republic
⨯
Leslie Michels Thompson,

Affiliation Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, California, United States of America
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Vitezslav Bryja,

Affiliations Department of Animal Physiology and Immunology, Institute of Experimental Biology, Masaryk University, Brno, Czech Republic, Department of Cytokinetics, Institute of Biophysics ASCR, Brno, Czech Republic
⨯
Alois Kozubik,

Affiliations Department of Animal Physiology and Immunology, Institute of Experimental Biology, Masaryk University, Brno, Czech Republic, Department of Cytokinetics, Institute of Biophysics ASCR, Brno, Czech Republic
⨯
William R. Wilcox

Affiliations Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America, Department of Pediatrics, University of California Los Angeles School of Medicine, Los Angeles, California, United States of America
⨯

Analysis of STAT1 Activation by Six FGFR3 Mutants Associated with Skeletal Dysplasia Undermines Dominant Role of STAT1 in FGFR3 Signaling in Cartilage

Pavel Krejci,
Lisa Salazar,
Tamara A. Kashiwada,
Katarina Chlebova,
Alena Salasova,
Leslie Michels Thompson,
Vitezslav Bryja,
Alois Kozubik,
William R. Wilcox

Published: December 17, 2008
https://doi.org/10.1371/journal.pone.0003961

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Transfection
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Chondrocytes
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293T cells
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Dysplasia
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STAT signaling
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Cartilage
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Tyrosine kinases
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