The Marine-Derived Oligosaccharide Sulfate (MdOS), a Novel Multiple Tyrosine Kinase Inhibitor, Combats Tumor Angiogenesis both In Vitro and In Vivo

Jingui Ma; Xianliang Xin; Linghua Meng; Linjiang Tong; Liping Lin; Meiyu Geng; Jian Ding

doi:10.1371/journal.pone.0003774

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Peer-reviewed

Research Article

The Marine-Derived Oligosaccharide Sulfate (MdOS), a Novel Multiple Tyrosine Kinase Inhibitor, Combats Tumor Angiogenesis both In Vitro and In Vivo

Jingui Ma,

Affiliation Division of Anti-Tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
⨯
Xianliang Xin,

Affiliation Division of Anti-Tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
⨯
Linghua Meng,

Affiliation Division of Anti-Tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
⨯
Linjiang Tong,

Affiliation Division of Anti-Tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
⨯
Liping Lin,

Affiliation Division of Anti-Tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
⨯
Meiyu Geng ,

* E-mail: mygeng@mail.shcnc.ac.cn (MG); suozhang@mail.shcnc.ac.cn (JD)

Affiliation Division of Anti-Tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
⨯
Jian Ding

* E-mail: mygeng@mail.shcnc.ac.cn (MG); suozhang@mail.shcnc.ac.cn (JD)

Affiliation Division of Anti-Tumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
⨯

The Marine-Derived Oligosaccharide Sulfate (MdOS), a Novel Multiple Tyrosine Kinase Inhibitor, Combats Tumor Angiogenesis both In Vitro and In Vivo

Jingui Ma,
Xianliang Xin,
Linghua Meng,
Linjiang Tong,
Liping Lin,
Meiyu Geng,
Jian Ding

Published: November 20, 2008
https://doi.org/10.1371/journal.pone.0003774

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