Concept, Design and Implementation of a Cardiovascular Gene-Centric 50 K SNP Array for Large-Scale Genomic Association Studies

• Brendan J. Keating,

  Affiliation The Institute for Translational Medicine and Therapeutics, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvannia, United States of America

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• Sam Tischfield,

  Affiliations Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Divisions of Genetics, Endocrinology & Program in Genomics, Children's Hospital, Boston, Massachusetts, United States of America

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• Sarah S. Murray,

  Affiliation Scripps Genomic Medicine, La Jolla, California, United States of America

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• Tushar Bhangale,

  Affiliation Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America

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• Thomas S. Price,

  Affiliation MRC SGDP Centre, Institute of Psychiatry, London, United Kingdom

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• Joseph T. Glessner,

  Affiliation The Center for Applied Genomics, Division of Human Genetics, Department of Pediatrics, The Childrens' Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

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• Luana Galver,

  Affiliation Illumina Incorporated, San Diego, California, United States of America

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• Jeffrey C. Barrett,

  Affiliation The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

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• Struan F. A. Grant,

  Affiliation The Center for Applied Genomics, Division of Human Genetics, Department of Pediatrics, The Childrens' Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

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• Deborah N. Farlow,

  Affiliation Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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• Hareesh R. Chandrupatla,

  Affiliation The Cardiovascular Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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• Mark Hansen,

  Affiliation Illumina Incorporated, San Diego, California, United States of America

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• Saad Ajmal,

  Affiliation The Cardiovascular Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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• George J. Papanicolaou,

  Affiliation Division of Prevention and Population Sciences, National Heart, Lung, and Blood Institute, Bethesda, Maryland, United States of America

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• Yiran Guo,

  Affiliation Beijing Genomics Institute at Shenzhen, Shenzhen, China

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• Mingyao Li,

  Affiliation The Cardiovascular Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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• Stephanie DerOhannessian,

  Affiliation The Cardiovascular Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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• Paul I. W. de Bakker,

  Affiliations Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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• Swneke D. Bailey,

  Affiliation Departments of Medicine and Human Genetics, McGill University, Montréal, Québec, Canada

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• Alexandre Montpetit,

  Affiliation Genome Québec Innovation Centre, Montréal , Québec, Canada

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• Andrew C. Edmondson,

  Affiliation The Cardiovascular Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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• Kent Taylor,

  Affiliation Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States of America

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• Xiaowu Gai,

  Affiliation The Center for Applied Genomics, Division of Human Genetics, Department of Pediatrics, The Childrens' Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

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• Susanna S. Wang,

  Affiliation Department of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

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• Myriam Fornage,

  Affiliation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas, United States of America

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• Tamim Shaikh,

  Affiliation The Center for Applied Genomics, Division of Human Genetics, Department of Pediatrics, The Childrens' Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

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• Leif Groop,

  Affiliation Department of Clinical Science Malmoe, Diabetes and Endocrinology, Lund University, Sweden and Department of Medicine, Helsinki University Hospital, Helsinki, Finland

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• Michael Boehnke,

  Affiliation Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America

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• Alistair S. Hall,

  Affiliation Leeds Institute of Genetics, Health & Therapeutics, University of Leeds, Leeds, United Kingdom

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• Andrew T. Hattersley,

  Affiliation Diabetes Genetics Group, Institute of Biomedical and Clinical Science, Peninsula Medical School, Exeter, United Kingdom

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• Edward Frackelton,

  Affiliation The Center for Applied Genomics, Division of Human Genetics, Department of Pediatrics, The Childrens' Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

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• Nick Patterson,

  Affiliation Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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• Charleston W. K. Chiang,

  Affiliations Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

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• Cecelia E. Kim,

  Affiliation The Center for Applied Genomics, Division of Human Genetics, Department of Pediatrics, The Childrens' Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

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• Richard R. Fabsitz,

  Affiliation Division of Prevention and Population Sciences, National Heart, Lung, and Blood Institute, Bethesda, Maryland, United States of America

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• Willem Ouwehand,

  Affiliation Department of Haematology and NHS Blood and Transplant, University of Cambridge, Cambridge, United Kingdom

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• Alkes L. Price,

  Affiliation Departments of Epidemiology and Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America

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• Patricia Munroe,

  Affiliations Department of Clinical Pharmacology, Barts and The London, Charterhouse Square, London, United Kingdom, William Harvey Research Institute, Barts and The London, Charterhouse Square, London, United Kingdom

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• Mark Caulfield,

  Affiliation William Harvey Research Institute, Barts and The London, Charterhouse Square, London, United Kingdom

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• Thomas Drake,

  Affiliation Department of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

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• Eric Boerwinkle,

  Affiliation Human Genetics Center, University of Texas Health Science Center, Houston, Texas, United States of America

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• David Reich,

  Affiliations Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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• A. Stephen Whitehead,

  Affiliation The Institute for Translational Medicine and Therapeutics, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvannia, United States of America

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• Thomas P. Cappola,

  Affiliation The Cardiovascular Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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• Nilesh J. Samani,

  Affiliation Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom

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• A. Jake Lusis,

  Affiliations Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles School of Medicine, Los Angeles, California, United States of America, Department of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

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• Eric Schadt,

  Affiliation Rosetta Inpharmatics, LLC, Merck & Co. Inc., Seattle, Washington, United States of America

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• James G. Wilson,

  Affiliation V.A. Medical Center and the University of Mississippi Medical Center, Jackson, Mississippi, United States of America

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• Wolfgang Koenig,

  Affiliation Department of Internal Medicine II - Cardiology, University of Ulm Medical Center, Ulm, Germany

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• Mark I. McCarthy,

  Affiliations The Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom, Oxford Center for Diabetes, Endocrinology and Metabolism and Oxford NIHR Biomedical Research Center, Churchill Hospital, University of Oxford, Oxford, United Kingdom

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• Sekar Kathiresan,

  Affiliations Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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• Stacey B. Gabriel,

  Affiliation Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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• Hakon Hakonarson,

  Affiliation The Center for Applied Genomics, Division of Human Genetics, Department of Pediatrics, The Childrens' Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

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• Sonia S. Anand,

  Affiliation Department of Medicine and Clinical Epidemiology and Biostatistics, Population Genomics Program, McMaster University, Hamilton Health Sciences, Hamilton General Hospital, Hamilton, Ontario, Canada

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• Muredach Reilly,

  Affiliations The Institute for Translational Medicine and Therapeutics, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvannia, United States of America, The Cardiovascular Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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• James C. Engert,

  Affiliation Departments of Medicine and Human Genetics, McGill University, Montréal, Québec, Canada

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• Deborah A. Nickerson,

  Affiliation Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America

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• Daniel J. Rader,

  Affiliations The Institute for Translational Medicine and Therapeutics, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvannia, United States of America, The Cardiovascular Institute, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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• Joel N. Hirschhorn,

  Affiliations Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Divisions of Genetics, Endocrinology & Program in Genomics, Children's Hospital, Boston, Massachusetts, United States of America, Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

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•  [ ... ],
• Garret A. FitzGerald

  * E-mail: garret@spirit.gcrc.upenn.edu

  Affiliation The Institute for Translational Medicine and Therapeutics, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvannia, United States of America

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