Endogenous VEGF Is Required for Visual Function: Evidence for a Survival Role on Müller Cells and Photoreceptors

Magali Saint-Geniez; Arindel S. R. Maharaj; Tony E. Walshe; Budd A. Tucker; Eiichi Sekiyama; Tomoki Kurihara; Diane C. Darland; Michael J. Young; Patricia A. D'Amore

doi:10.1371/journal.pone.0003554

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Peer-reviewed

Research Article

Endogenous VEGF Is Required for Visual Function: Evidence for a Survival Role on Müller Cells and Photoreceptors

Magali Saint-Geniez,

Affiliations Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Arindel S. R. Maharaj,

Affiliation Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Tony E. Walshe,

Affiliations Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Budd A. Tucker,

Affiliations Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Eiichi Sekiyama,

Affiliations Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Tomoki Kurihara,

Affiliation Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Diane C. Darland,

Affiliation University of North Dakota, Grand Forks, North Dakota, United States of America
⨯
Michael J. Young,

Affiliations Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Patricia A. D'Amore

* E-mail: patricia.damore@schepens.harvard.edu

Affiliations Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America
⨯

Endogenous VEGF Is Required for Visual Function: Evidence for a Survival Role on Müller Cells and Photoreceptors

Magali Saint-Geniez,
Arindel S. R. Maharaj,
Tony E. Walshe,
Budd A. Tucker,
Eiichi Sekiyama,
Tomoki Kurihara,
Diane C. Darland,
Michael J. Young,
Patricia A. D'Amore

Published: November 3, 2008
https://doi.org/10.1371/journal.pone.0003554

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Retina
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Photoreceptors
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Apoptosis
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Retinal vessels
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Cell staining
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VEGF signaling
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