Gene Disruption of Plasmodium falciparum p52 Results in Attenuation of Malaria Liver Stage Development in Cultured Primary Human Hepatocytes

Ben C. L. van Schaijk; Chris J. Janse; Geert-Jan van Gemert; Melissa R. van Dijk; Audrey Gego; Jean-Francois Franetich; Marga van de Vegte-Bolmer; Samir Yalaoui; Olivier Silvie; Stephen L. Hoffman; Andrew P. Waters; Dominique Mazier; Robert W. Sauerwein; Shahid M. Khan

doi:10.1371/journal.pone.0003549

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Open Access

Peer-reviewed

Research Article

Gene Disruption of Plasmodium falciparum p52 Results in Attenuation of Malaria Liver Stage Development in Cultured Primary Human Hepatocytes

Ben C. L. van Schaijk,

Affiliation Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
⨯
Chris J. Janse,

Affiliation Department of Parasitology, Leiden University Medical Centre, Leiden, The Netherlands
⨯
Geert-Jan van Gemert,

Affiliation Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
⨯
Melissa R. van Dijk,

Affiliation Department of Parasitology, Leiden University Medical Centre, Leiden, The Netherlands
⨯
Audrey Gego,

Affiliations INSERM, U511, Paris, France, Université Pierre et Marie Curie-Paris6, UMR S511 Paris, France
⨯
Jean-Francois Franetich,

Affiliations INSERM, U511, Paris, France, Université Pierre et Marie Curie-Paris6, UMR S511 Paris, France
⨯
Marga van de Vegte-Bolmer,

Affiliation Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
⨯
Samir Yalaoui,

Affiliations INSERM, U511, Paris, France, Université Pierre et Marie Curie-Paris6, UMR S511 Paris, France
⨯
Olivier Silvie,

Affiliations INSERM, U511, Paris, France, Université Pierre et Marie Curie-Paris6, UMR S511 Paris, France
⨯
Stephen L. Hoffman,

Affiliation Sanaria Inc., Rockville, Maryland, United States of America
⨯
Andrew P. Waters,

Affiliation Department of Parasitology, Leiden University Medical Centre, Leiden, The Netherlands
⨯
Dominique Mazier,

Affiliations INSERM, U511, Paris, France, Université Pierre et Marie Curie-Paris6, UMR S511 Paris, France, AP-HP, Groupe hospitalier Pitié-Salpêtrière, Service Parasitologie-Mycologie, Paris, France
⨯
Robert W. Sauerwein,

Affiliation Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
⨯
Shahid M. Khan

* E-mail: s.m.khan@lumc.nl

Affiliation Department of Parasitology, Leiden University Medical Centre, Leiden, The Netherlands
⨯

Gene Disruption of Plasmodium falciparum p52 Results in Attenuation of Malaria Liver Stage Development in Cultured Primary Human Hepatocytes

Ben C. L. van Schaijk,
Chris J. Janse,
Geert-Jan van Gemert,
Melissa R. van Dijk,
Audrey Gego,
Jean-Francois Franetich,
Marga van de Vegte-Bolmer,
Samir Yalaoui,
Olivier Silvie,
Stephen L. Hoffman

Published: October 28, 2008
https://doi.org/10.1371/journal.pone.0003549

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