Cdx1 and c-Myc Foster the Initiation of Transdifferentiation of the Normal Esophageal Squamous Epithelium toward Barrett's Esophagus

Douglas B. Stairs; Hiroshi Nakagawa; Andres Klein-Szanto; Shukriyyah D. Mitchell; Debra G. Silberg; John W. Tobias; John P. Lynch; Anil K. Rustgi

doi:10.1371/journal.pone.0003534

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Peer-reviewed

Research Article

Cdx1 and c-Myc Foster the Initiation of Transdifferentiation of the Normal Esophageal Squamous Epithelium toward Barrett's Esophagus

Douglas B. Stairs,

Affiliations Division of Gastroenterology, Department of Medicine, Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Division of Gastroenterology, Department of Genetics, Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
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Hiroshi Nakagawa,

Affiliations Division of Gastroenterology, Department of Medicine, Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Division of Gastroenterology, Department of Genetics, Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Andres Klein-Szanto,

Affiliation Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America
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Shukriyyah D. Mitchell,

Affiliations Division of Gastroenterology, Department of Medicine, Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Division of Gastroenterology, Department of Genetics, Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
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Debra G. Silberg,

Affiliations Division of Gastroenterology, Department of Medicine, Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Division of Gastroenterology, Department of Genetics, Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
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John W. Tobias,

Affiliation Penn Center for Bioinformatics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
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John P. Lynch,

Affiliations Division of Gastroenterology, Department of Medicine, Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Division of Gastroenterology, Department of Genetics, Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Anil K. Rustgi

Affiliations Division of Gastroenterology, Department of Medicine, Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Division of Gastroenterology, Department of Genetics, Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯

Cdx1 and c-Myc Foster the Initiation of Transdifferentiation of the Normal Esophageal Squamous Epithelium toward Barrett's Esophagus

Douglas B. Stairs,
Hiroshi Nakagawa,
Andres Klein-Szanto,
Shukriyyah D. Mitchell,
Debra G. Silberg,
John W. Tobias,
John P. Lynch,
Anil K. Rustgi

Published: October 27, 2008
https://doi.org/10.1371/journal.pone.0003534

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11 Nov 2008
19:59 GMT
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Publisher's Note: Correction to Figure 5 Posted by PLOS_ONE_Group on 11 Nov 2008 at 19:59 GMT

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Barrett's esophagus
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Epithelium
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Keratins
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Transdifferentiation
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Gastrointestinal tract
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Gene expression
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