A Non-Canonical Function of Zebrafish Telomerase Reverse Transcriptase Is Required for Developmental Hematopoiesis

Shintaro Imamura; Junzo Uchiyama; Eriko Koshimizu; Jun-ichi Hanai; Christina Raftopoulou; Ryan D. Murphey; Peter E. Bayliss; Yoichi Imai; Caroline Erter Burns; Kenkichi Masutomi; Sarantis Gagos; Leonard I. Zon; Thomas M. Roberts; Shuji Kishi

doi:10.1371/journal.pone.0003364

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Peer-reviewed

Research Article

A Non-Canonical Function of Zebrafish Telomerase Reverse Transcriptase Is Required for Developmental Hematopoiesis

Shintaro Imamura ,

Contributed equally to this work with: Shintaro Imamura, Junzo Uchiyama

Affiliation Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Junzo Uchiyama ,

Contributed equally to this work with: Shintaro Imamura, Junzo Uchiyama

Affiliation Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Eriko Koshimizu,

Affiliation Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Jun-ichi Hanai,

Affiliation Renal Division, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America
⨯
Christina Raftopoulou,

Affiliation Laboratory of Genetics, Biomedical Research Foundation of the Academy of Athens Greece, Athens, Greece
⨯
Ryan D. Murphey,

Affiliation Stem Cell Program and Division of Hematology/Oncology, Children's Hospital Boston, Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Peter E. Bayliss,

Affiliation Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Yoichi Imai,

Affiliation The CBR Institute for Biomedical Research, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Caroline Erter Burns,

Affiliation Stem Cell Program and Division of Hematology/Oncology, Children's Hospital Boston, Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Kenkichi Masutomi,

Affiliation Cancer Stem Cell Project, National Cancer Center, Tokyo, Japan
⨯
Sarantis Gagos,

Affiliation Laboratory of Genetics, Biomedical Research Foundation of the Academy of Athens Greece, Athens, Greece
⨯
Leonard I. Zon,

Affiliation Stem Cell Program and Division of Hematology/Oncology, Children's Hospital Boston, Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Thomas M. Roberts,

Affiliation Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Shuji Kishi

* E-mail: s.kishi@mac.com

Affiliation Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, United States of America
⨯

A Non-Canonical Function of Zebrafish Telomerase Reverse Transcriptase Is Required for Developmental Hematopoiesis

Shintaro Imamura,
Junzo Uchiyama,
Eriko Koshimizu,
Jun-ichi Hanai,
Christina Raftopoulou,
Ryan D. Murphey,
Peter E. Bayliss,
Yoichi Imai,
Caroline Erter Burns,
Kenkichi Masutomi

Published: October 10, 2008
https://doi.org/10.1371/journal.pone.0003364

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