CHEK2 Mutations Affecting Kinase Activity Together With Mutations in TP53 Indicate a Functional Pathway Associated with Resistance to Epirubicin in Primary Breast Cancer

• Ranjan Chrisanthar,

  Affiliations Section of Oncology, Institute of Medicine, University of Bergen, Bergen, Norway, Department of Oncology, Haukeland University Hospital, Bergen, Norway, Department of Molecular Biology, University of Bergen, Bergen, Norway

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• Stian Knappskog,

  Affiliations Section of Oncology, Institute of Medicine, University of Bergen, Bergen, Norway, Department of Oncology, Haukeland University Hospital, Bergen, Norway, Department of Molecular Biology, University of Bergen, Bergen, Norway

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• Erik Løkkevik,

  Affiliation Department of Oncology, The Norwegian Radium Hospital, Rikshospitalet University Hospital, Oslo, Norway

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• Gun Anker,

  Affiliations Section of Oncology, Institute of Medicine, University of Bergen, Bergen, Norway, Department of Oncology, Haukeland University Hospital, Bergen, Norway

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• Bjørn Østenstad,

  Affiliation Department of Oncology, Ullevaal University Hospital, Oslo, Norway

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• Steinar Lundgren,

  Affiliations Department of Oncology, St. Olav University Hospital, Trondheim, Norway, Norwegian University of Science and Technology, Department of Cancer Research and Molecular Medicine, Trondheim, Norway

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• Elisabet O. Berge,

  Affiliation Department of Molecular Biology, University of Bergen, Bergen, Norway

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• Terje Risberg,

  Affiliation Department of Oncology, University Hospital of Northern Norway and Institute of Clinical Medicine, University of Tromsø, Tromsø, Norway

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• Ingvil Mjaaland,

  Affiliation Division of Hematology and Oncology, Stavanger University Hospital, Stavanger, Norway

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• Lovise Mæhle,

  Affiliation Department of Medical Genetics, Rikshospitalet University Hospital, Oslo, Norway

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• Lars Fredrik Engebretsen,

  Affiliation Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway

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• Johan Richard Lillehaug,

  Affiliation Department of Molecular Biology, University of Bergen, Bergen, Norway

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• Per Eystein Lønning

  * E-mail: per.lonning@helse-bergen.no

  Affiliations Section of Oncology, Institute of Medicine, University of Bergen, Bergen, Norway, Department of Oncology, Haukeland University Hospital, Bergen, Norway

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