Dorsomorphin, a Selective Small Molecule Inhibitor of BMP Signaling, Promotes Cardiomyogenesis in Embryonic Stem Cells

Jijun Hao; Marie A. Daleo; Clare K. Murphy; Paul B. Yu; Joshua N. Ho; Jianyong Hu; Randall T. Peterson; Antonis K. Hatzopoulos; Charles C. Hong

doi:10.1371/journal.pone.0002904

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Peer-reviewed

Research Article

Dorsomorphin, a Selective Small Molecule Inhibitor of BMP Signaling, Promotes Cardiomyogenesis in Embryonic Stem Cells

Jijun Hao,

Affiliation Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
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Marie A. Daleo,

Affiliation Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
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Clare K. Murphy,

Affiliation Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
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Paul B. Yu,

Affiliation Cardiovascular Research Center and Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
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Joshua N. Ho,

Affiliation Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
⨯
Jianyong Hu,

Affiliations Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
⨯
Randall T. Peterson,

Affiliation Cardiovascular Research Center and Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
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Antonis K. Hatzopoulos,

Affiliations Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
⨯
Charles C. Hong

* E-mail: charles.c.hong@vanderbilt.edu

Affiliations Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America, Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
⨯

Dorsomorphin, a Selective Small Molecule Inhibitor of BMP Signaling, Promotes Cardiomyogenesis in Embryonic Stem Cells

Jijun Hao,
Marie A. Daleo,
Clare K. Murphy,
Paul B. Yu,
Joshua N. Ho,
Jianyong Hu,
Randall T. Peterson,
Antonis K. Hatzopoulos,
Charles C. Hong

Published: August 6, 2008
https://doi.org/10.1371/journal.pone.0002904

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Cell differentiation
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Cardiomyocytes
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BMP signaling
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Small molecules
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Stem cells
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Pluripotency
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Signal inhibition
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Stem cell therapy
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