A RasGAP SH3 Peptide Aptamer Inhibits RasGAP-Aurora Interaction and Induces Caspase-Independent Tumor Cell Death

Perayot Pamonsinlapatham; Réda Hadj-Slimane; Françoise Raynaud; Marc Bickle; Claudine Corneloup; Audrey Barthelaix; Yves Lepelletier; Perrine Mercier; Matthieu Schapira; Jérôme Samson; Anne-Laure Mathieu; Nicolas Hugo; Olivier Moncorgé; Ivan Mikaelian; Sylvie Dufour; Christiane Garbay; Pierre Colas

doi:10.1371/journal.pone.0002902

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Research Article

A RasGAP SH3 Peptide Aptamer Inhibits RasGAP-Aurora Interaction and Induces Caspase-Independent Tumor Cell Death

Perayot Pamonsinlapatham ,

Contributed equally to this work with: Perayot Pamonsinlapatham, Réda Hadj-Slimane, Françoise Raynaud

Affiliation Université Paris Descartes, UFR Biomédicale, Laboratoire de Pharmacochimie Moléculaire et Cellulaire, INSERM U648, Paris, France
⨯
Réda Hadj-Slimane ,

Contributed equally to this work with: Perayot Pamonsinlapatham, Réda Hadj-Slimane, Françoise Raynaud

Affiliation Université Paris Descartes, UFR Biomédicale, Laboratoire de Pharmacochimie Moléculaire et Cellulaire, INSERM U648, Paris, France
⨯
Françoise Raynaud ,

Contributed equally to this work with: Perayot Pamonsinlapatham, Réda Hadj-Slimane, Françoise Raynaud

Affiliation Université Paris Descartes, UFR Biomédicale, Laboratoire de Pharmacochimie Moléculaire et Cellulaire, INSERM U648, Paris, France
⨯
Marc Bickle,

Affiliation Aptanomics, Lyon, France
⨯
Claudine Corneloup,

Affiliation Aptanomics, Lyon, France
⨯
Audrey Barthelaix,

Affiliation Aptanomics, Lyon, France
⨯
Yves Lepelletier,

Affiliation Université Paris Descartes, Hôpital Necker, CNRS UMR 8147, Paris, France
⨯
Perrine Mercier,

Affiliation Aptanomics, Lyon, France
⨯
Matthieu Schapira,

Affiliation Aptanomics, Lyon, France
⨯
Jérôme Samson,

Affiliation Université Paris Descartes, UFR Biomédicale, Laboratoire de Pharmacochimie Moléculaire et Cellulaire, INSERM U648, Paris, France
⨯
Anne-Laure Mathieu,

Affiliation Aptanomics, Lyon, France
⨯
Nicolas Hugo,

Affiliation Aptanomics, Lyon, France
⨯
Olivier Moncorgé,

Affiliation Aptanomics, Lyon, France
⨯
Ivan Mikaelian,

Affiliation Aptanomics, Lyon, France
⨯
Sylvie Dufour,

Affiliation UMR CNRS 144, Institut Curie, 26, Paris, France
⨯
Christiane Garbay ,

* E-mail: christiane.garbay@univ-paris5.fr

Affiliation Université Paris Descartes, UFR Biomédicale, Laboratoire de Pharmacochimie Moléculaire et Cellulaire, INSERM U648, Paris, France
⨯
[ ... ],
Pierre Colas

Current address: (PC) CNRS UPS 2682, Station Biologique, Roscoff, France

Affiliation Aptanomics, Lyon, France
⨯
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A RasGAP SH3 Peptide Aptamer Inhibits RasGAP-Aurora Interaction and Induces Caspase-Independent Tumor Cell Death

Perayot Pamonsinlapatham,
Réda Hadj-Slimane,
Françoise Raynaud,
Marc Bickle,
Claudine Corneloup,
Audrey Barthelaix,
Yves Lepelletier,
Perrine Mercier,
Matthieu Schapira,
Jérôme Samson

Published: August 6, 2008
https://doi.org/10.1371/journal.pone.0002902

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