Optimal Probe Length Varies for Targets with High Sequence Variation: Implications for Probe Library Design for Resequencing Highly Variable Genes

Open Access

Peer-reviewed

Research Article

Niall J. Haslam ,

* E-mail: haslam@embl.de

Affiliation School of Chemistry, University of Southampton, Southhampton, United Kingdom
⨯
Nava E. Whiteford,

Affiliation School of Chemistry, University of Southampton, Southhampton, United Kingdom
⨯
Gerald Weber,

Affiliations School of Chemistry, University of Southampton, Southhampton, United Kingdom, Departamento de Fisica, Universidade Federal de Ouro Preto, Instituto de Ciências Exatas e Biológicas, Ouro Preto, Brasil
⨯
Adam Prügel-Bennett,

Affiliation School of Engineering and Computer Science, University of Southampton, Southhampton, United Kingdom
⨯
Jonathan W. Essex,

Affiliation School of Chemistry, University of Southampton, Southhampton, United Kingdom
⨯
Cameron Neylon

Affiliations School of Chemistry, University of Southampton, Southhampton, United Kingdom, STFC Rutherford Appleton Laboratory, Harwell Science and Innovation Campus, Didcot, Oxfordshire, United Kingdom
⨯

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Probe hybridization
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HIV
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Drug discovery
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Gene targeting
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Nucleotide sequencing
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Proteases
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DNA libraries
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Thermodynamics
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