A Regulatory Role for NBS1 in Strand-Specific Mutagenesis during Somatic Hypermutation

Likun Du; Deborah K. Dunn-Walters; Krystyna H. Chrzanowska; Tanja Stankovic; Ashwin Kotnis; Xin Li; Jiayi Lu; Gösta Eggertsen; Claire Brittain; Sergey W. Popov; Andrew R. Gennery; A. Malcolm R. Taylor; Qiang Pan-Hammarström

doi:10.1371/journal.pone.0002482

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Open Access

Peer-reviewed

Research Article

A Regulatory Role for NBS1 in Strand-Specific Mutagenesis during Somatic Hypermutation

Likun Du,

Affiliation Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden
⨯
Deborah K. Dunn-Walters,

Affiliation Department of Immunobiology, King's College London School of Medicine, Guy's Hospital, London, United Kingdom
⨯
Krystyna H. Chrzanowska,

Affiliation Department of Medical Genetics, the Children's Memorial Health Institute, Warsaw, Poland
⨯
Tanja Stankovic,

Affiliation The University of Birmingham CRC Institute for Cancer Studies, the Medical School Edghaston, Birmingham, United Kingdom
⨯
Ashwin Kotnis,

Affiliation Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden
⨯
Xin Li,

Affiliation Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden
⨯
Jiayi Lu,

Affiliation Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden
⨯
Gösta Eggertsen,

Affiliation Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden
⨯
Claire Brittain,

Affiliation The University of Birmingham CRC Institute for Cancer Studies, the Medical School Edghaston, Birmingham, United Kingdom
⨯
Sergey W. Popov,

Affiliation Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden
⨯
Andrew R. Gennery,

Affiliation Department of Pediatric Immunology, Newcastle General Hospital, Newcastle, United Kingdom
⨯
A. Malcolm R. Taylor,

Affiliation The University of Birmingham CRC Institute for Cancer Studies, the Medical School Edghaston, Birmingham, United Kingdom
⨯
Qiang Pan-Hammarström

* E-mail: Qiang.Pan-Hammarstrom@ki.se

Affiliation Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, Sweden
⨯

A Regulatory Role for NBS1 in Strand-Specific Mutagenesis during Somatic Hypermutation

Likun Du,
Deborah K. Dunn-Walters,
Krystyna H. Chrzanowska,
Tanja Stankovic,
Ashwin Kotnis,
Xin Li,
Jiayi Lu,
Gösta Eggertsen,
Claire Brittain,
Sergey W. Popov

Published: June 25, 2008
https://doi.org/10.1371/journal.pone.0002482

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Substitution mutation
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Cloning
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Sequence motif analysis
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DNA repair
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B cells
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Polymerase chain reaction
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Base excision repair
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