HDAC Inhibitors Act with 5-aza-2′-Deoxycytidine to Inhibit Cell Proliferation by Suppressing Removal of Incorporated Abases in Lung Cancer Cells

Guolin Chai; Lian Li; Wen Zhou; Lipeng Wu; Ying Zhao; Donglai Wang; Shaoli Lu; Yu Yu; Haiying Wang; Michael A. McNutt; Ye-Guang Hu; Yingqi Chen; Yang Yang; Xin Wu; Gregory A. Otterson; Wei-Guo Zhu

doi:10.1371/journal.pone.0002445

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Open Access

Peer-reviewed

Research Article

HDAC Inhibitors Act with 5-aza-2′-Deoxycytidine to Inhibit Cell Proliferation by Suppressing Removal of Incorporated Abases in Lung Cancer Cells

Guolin Chai ,

Contributed equally to this work with: Guolin Chai, Lian Li, Wen Zhou

Affiliation Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing, China
⨯
Lian Li ,

Contributed equally to this work with: Guolin Chai, Lian Li, Wen Zhou

Affiliation Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing, China
⨯
Wen Zhou ,

Contributed equally to this work with: Guolin Chai, Lian Li, Wen Zhou

Affiliation Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing, China
⨯
Lipeng Wu,

Affiliation Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing, China
⨯
Ying Zhao,

Affiliation Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing, China
⨯
Donglai Wang,

Affiliation Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing, China
⨯
Shaoli Lu,

Affiliation Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing, China
⨯
Yu Yu,

Affiliation Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing, China
⨯
Haiying Wang,

Affiliation Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing, China
⨯
Michael A. McNutt,

Affiliation Department of Pathology, Peking University Health Science Center, Beijing, China
⨯
Ye-Guang Hu,

Affiliation State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China
⨯
Yingqi Chen,

Affiliation Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing, China
⨯
Yang Yang,

Affiliation Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing, China
⨯
Xin Wu,

Affiliation Department of Internal Medicine, Division of Hematology Oncology, Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, United States of America
⨯
Gregory A. Otterson,

Affiliation Department of Internal Medicine, Division of Hematology Oncology, Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, United States of America
⨯
[ ... ],
Wei-Guo Zhu

* E-mail: zhuweiguo@bjmu.edu.cn

Affiliation Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing, China
⨯
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HDAC Inhibitors Act with 5-aza-2′-Deoxycytidine to Inhibit Cell Proliferation by Suppressing Removal of Incorporated Abases in Lung Cancer Cells

Guolin Chai,
Lian Li,
Wen Zhou,
Lipeng Wu,
Ying Zhao,
Donglai Wang,
Shaoli Lu,
Yu Yu,
Haiying Wang,
Michael A. McNutt

Published: June 18, 2008
https://doi.org/10.1371/journal.pone.0002445

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