Chromosomal Instability by Inefficient Mps1 Auto-Activation Due to a Weakened Mitotic Checkpoint and Lagging Chromosomes

• Nannette Jelluma,

  Affiliations Department of Physiological Chemistry and Cancer Genomics Centre, UMC Utrecht, Utrecht, The Netherlands, Department of Medical Oncology, Laboratory of Experimental Oncology, UMC Utrecht, Utrecht, The Netherlands

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• Arjan B. Brenkman,

  Affiliation Department of Physiological Chemistry and Cancer Genomics Centre, UMC Utrecht, Utrecht, The Netherlands

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• Ian McLeod,

  Affiliation Department of Cell Biology, The Scripps Research Institute, La Jolla, California, United States of America

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• John R. Yates III,

  Affiliation Department of Cell Biology, The Scripps Research Institute, La Jolla, California, United States of America

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• Don W. Cleveland,

  Affiliation Ludwig Institute for Cancer Research and Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, California, United States of America

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• René H. Medema,

  Affiliation Department of Medical Oncology, Laboratory of Experimental Oncology, UMC Utrecht, Utrecht, The Netherlands

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• Geert J. P. L. Kops

  * E-mail: g.j.p.l.kops@umcutrecht.nl

  Affiliations Department of Physiological Chemistry and Cancer Genomics Centre, UMC Utrecht, Utrecht, The Netherlands, Department of Medical Oncology, Laboratory of Experimental Oncology, UMC Utrecht, Utrecht, The Netherlands

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