Directed Evolution Generates a Novel Oncolytic Virus for the Treatment of Colon Cancer

Irene Kuhn; Paul Harden; Maxine Bauzon; Cecile Chartier; Julie Nye; Steve Thorne; Tony Reid; Shaoheng Ni; Andre Lieber; Kerry Fisher; Len Seymour; Gabor M. Rubanyi; Richard N. Harkins; Terry W. Hermiston

doi:10.1371/journal.pone.0002409

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Open Access

Peer-reviewed

Research Article

Directed Evolution Generates a Novel Oncolytic Virus for the Treatment of Colon Cancer

Irene Kuhn,

Affiliation Novel Technologies, Bayer Healthcare, Richmond, California, United States of America
⨯
Paul Harden,

Affiliation Novel Technologies, Bayer Healthcare, Richmond, California, United States of America
⨯
Maxine Bauzon,

Affiliation Novel Technologies, Bayer Healthcare, Richmond, California, United States of America
⨯
Cecile Chartier,

Affiliation Novel Technologies, Bayer Healthcare, Richmond, California, United States of America
⨯
Julie Nye,

Affiliation Novel Technologies, Bayer Healthcare, Richmond, California, United States of America
⨯
Steve Thorne,

Affiliation Palo Alto Veteran's Hospital and Stanford University, Palo Alto, California, United States of America
⨯
Tony Reid,

Affiliation Palo Alto Veteran's Hospital and Stanford University, Palo Alto, California, United States of America
⨯
Shaoheng Ni,

Affiliation Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, Washington, United States of America
⨯
Andre Lieber,

Affiliation Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, Washington, United States of America
⨯
Kerry Fisher,

Affiliation Hybrid systems Ltd, Oxfordshire, United Kingdom
⨯
Len Seymour,

Affiliation Hybrid systems Ltd, Oxfordshire, United Kingdom
⨯
Gabor M. Rubanyi,

Affiliation Novel Technologies, Bayer Healthcare, Richmond, California, United States of America
⨯
Richard N. Harkins,

Affiliation Novel Technologies, Bayer Healthcare, Richmond, California, United States of America
⨯
Terry W. Hermiston

* E-mail: Terry.Hermiston@Bayer.com

Affiliation Novel Technologies, Bayer Healthcare, Richmond, California, United States of America
⨯

Directed Evolution Generates a Novel Oncolytic Virus for the Treatment of Colon Cancer

Irene Kuhn,
Paul Harden,
Maxine Bauzon,
Cecile Chartier,
Julie Nye,
Steve Thorne,
Tony Reid,
Shaoheng Ni,
Andre Lieber,
Kerry Fisher

Published: June 18, 2008
https://doi.org/10.1371/journal.pone.0002409

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Cancer treatment
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Oncolytic viruses
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Colorectal cancer
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Malignant tumors
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Colon
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Hepatocellular carcinoma
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Cancers and neoplasms
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Viral replication
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