Drug Metabolism in Human Brain: High Levels of Cytochrome P4503A43 in Brain and Metabolism of Anti-Anxiety Drug Alprazolam to Its Active Metabolite

Open Access

Peer-reviewed

Research Article

Varsha Agarwal,

Affiliation Division of Molecular and Cellular Neuroscience, National Brain Research Centre, Nainwal Mode, Manesar, India
⨯
Reddy P. Kommaddi,

Affiliation Division of Molecular and Cellular Neuroscience, National Brain Research Centre, Nainwal Mode, Manesar, India
⨯
Khader Valli,

Affiliation Division of Molecular and Cellular Neuroscience, National Brain Research Centre, Nainwal Mode, Manesar, India
⨯
Daniel Ryder,

Affiliation Department of Biochemistry and Molecular Biology, University of Texas Medical School, Houston, Texas, United States of America
⨯
Thomas M. Hyde,

Affiliation Clinical Brain Disorders Branch, Section on Neuropathology, Division of Intramural Research Programs (DIRP)/National Institute of Mental Health (NIMH)/National Institutes of Health (NIH), Bethesda, Maryland, United States of America
⨯
Joel E. Kleinman,

Affiliation Clinical Brain Disorders Branch, Section on Neuropathology, Division of Intramural Research Programs (DIRP)/National Institute of Mental Health (NIMH)/National Institutes of Health (NIH), Bethesda, Maryland, United States of America
⨯
Henry W. Strobel,

Affiliation Department of Biochemistry and Molecular Biology, University of Texas Medical School, Houston, Texas, United States of America
⨯
Vijayalakshmi Ravindranath

* E-mail: vijir@nbrc.ac.in

Affiliation Division of Molecular and Cellular Neuroscience, National Brain Research Centre, Nainwal Mode, Manesar, India
⨯

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Drug metabolism
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Enzymes
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Gene expression
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Probe hybridization
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