Increased Aortic Calpain-1 Activity Mediates Age-Associated Angiotensin II Signaling of Vascular Smooth Muscle Cells

Liqun Jiang; Mingyi Wang; Jing Zhang; Robert E. Monticone; Richard Telljohann; Gaia Spinetti; Gianfranco Pintus; Edward G. Lakatta

doi:10.1371/journal.pone.0002231

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Peer-reviewed

Research Article

Increased Aortic Calpain-1 Activity Mediates Age-Associated Angiotensin II Signaling of Vascular Smooth Muscle Cells

Liqun Jiang,

Affiliation Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
⨯
Mingyi Wang ,

* E-mail: mingyiw@grc.nia.nih.gov

Affiliation Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
⨯
Jing Zhang,

Affiliation Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
⨯
Robert E. Monticone,

Affiliation Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
⨯
Richard Telljohann,

Affiliation Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
⨯
Gaia Spinetti,

Current address: Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Cardiovascolare, Gruppo Multimedica, Milano, Italy

Affiliation Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
⨯
Gianfranco Pintus,

Current address: Department of Biomedical Sciences, University of Sassari, Sassari, Italy

Affiliation Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
⨯
Edward G. Lakatta

Affiliation Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
⨯

Increased Aortic Calpain-1 Activity Mediates Age-Associated Angiotensin II Signaling of Vascular Smooth Muscle Cells

Liqun Jiang,
Mingyi Wang,
Jing Zhang,
Robert E. Monticone,
Richard Telljohann,
Gaia Spinetti,
Gianfranco Pintus,
Edward G. Lakatta

Published: May 21, 2008
https://doi.org/10.1371/journal.pone.0002231

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