Reducing AD-Like Pathology in 3xTg-AD Mouse Model by DNA Epitope Vaccine — A Novel Immunotherapeutic Strategy

• Nina Movsesyan ,

  Contributed equally to this work with: Nina Movsesyan, Anahit Ghochikyan

  Affiliations Department of Molecular Immunology, Institute for Molecular Medicine, Huntington Beach, California, United States of America, Institute for Brain Aging and Dementia, University of California Irvine, Irvine, California, United States of America

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• Anahit Ghochikyan ,

  Contributed equally to this work with: Nina Movsesyan, Anahit Ghochikyan

  Affiliation Department of Molecular Immunology, Institute for Molecular Medicine, Huntington Beach, California, United States of America

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• Mikayel Mkrtichyan,

  Affiliation Department of Molecular Immunology, Institute for Molecular Medicine, Huntington Beach, California, United States of America

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• Irina Petrushina,

  Affiliation Institute for Brain Aging and Dementia, University of California Irvine, Irvine, California, United States of America

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• Hayk Davtyan,

  Affiliation Department of Molecular Immunology, Institute for Molecular Medicine, Huntington Beach, California, United States of America

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• Purevdorj B. Olkhanud,

  Affiliation Immunotherapeutics Unit, Laboratory of Immunology, National Institute on Aging, Baltimore, Maryland, United States of America

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• Elizabeth Head,

  Affiliations Institute for Brain Aging and Dementia, University of California Irvine, Irvine, California, United States of America, Department of Neurology, University of California Irvine, Irvine, California, United States of America

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• Arya Biragyn,

  Affiliation Immunotherapeutics Unit, Laboratory of Immunology, National Institute on Aging, Baltimore, Maryland, United States of America

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• David H. Cribbs ,

  ¶These authors also contributed equally to this work.

  Affiliations Institute for Brain Aging and Dementia, University of California Irvine, Irvine, California, United States of America, Department of Neurology, University of California Irvine, Irvine, California, United States of America

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• Michael G. Agadjanyan

  * E-mail: magadjanyan@immed.org

  ¶These authors also contributed equally to this work.

  Affiliations Department of Molecular Immunology, Institute for Molecular Medicine, Huntington Beach, California, United States of America, Institute for Brain Aging and Dementia, University of California Irvine, Irvine, California, United States of America

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