The SIRT1 Deacetylase Suppresses Intestinal Tumorigenesis and Colon Cancer Growth

• Ron Firestein ,

  Contributed equally to this work with: Ron Firestein, Gil Blander, Shaday Michan

  Affiliations Paul F. Glenn Laboratories for the Biological Mechanisms of Aging, Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Department of Medical Oncology, Dana Farber Cancer Institute, and Broad Institute of Harvard and Massachusetts Institute of Technology, Boston, Massachusetts, United States of America

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• Gil Blander ,

  Contributed equally to this work with: Ron Firestein, Gil Blander, Shaday Michan

  Current address: Genstruct Inc., Cambridge, Massachusetts, United States of America

  Affiliation Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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• Shaday Michan ,

  Contributed equally to this work with: Ron Firestein, Gil Blander, Shaday Michan

  Affiliation Paul F. Glenn Laboratories for the Biological Mechanisms of Aging, Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America

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• Philipp Oberdoerffer,

  Affiliation Paul F. Glenn Laboratories for the Biological Mechanisms of Aging, Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America

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• Shuji Ogino,

  Affiliations Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America

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• Jennifer Campbell,

  Affiliation Paul F. Glenn Laboratories for the Biological Mechanisms of Aging, Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America

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• Anupama Bhimavarapu,

  Affiliation Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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• Sandra Luikenhuis,

  Current address: Magen Biosciences, Cambridge, Massachusetts, United States of America

  Affiliation Paul F. Glenn Laboratories for the Biological Mechanisms of Aging, Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America

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• Rafael de Cabo,

  Affiliation Laboratory of Experimental Gerontology, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America

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• Charles Fuchs,

  Affiliation Department of Medical Oncology, Dana Farber Cancer Institute, and Broad Institute of Harvard and Massachusetts Institute of Technology, Boston, Massachusetts, United States of America

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• William C. Hahn,

  Affiliation Department of Medical Oncology, Dana Farber Cancer Institute, and Broad Institute of Harvard and Massachusetts Institute of Technology, Boston, Massachusetts, United States of America

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• Leonard P. Guarente,

  Affiliation Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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• David A. Sinclair

  *To whom correspondence should be addressed. E-mail: david_sinclair@hms.harvard.edu

  Affiliation Paul F. Glenn Laboratories for the Biological Mechanisms of Aging, Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America

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