Strain-Specific Virulence Phenotypes of Streptococcus pneumoniae Assessed Using the Chinchilla laniger Model of Otitis Media

Michael L. Forbes; Edward Horsey; N. Luisa Hiller; Farrel J. Buchinsky; Jay D. Hayes; James M. Compliment; Todd Hillman; Suzanne Ezzo; Kai Shen; Randy Keefe; Karen Barbadora; J. Christopher Post; Fen Ze Hu; Garth D. Ehrlich

doi:10.1371/journal.pone.0001969

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Research Article

Strain-Specific Virulence Phenotypes of Streptococcus pneumoniae Assessed Using the Chinchilla laniger Model of Otitis Media

Michael L. Forbes ,

Contributed equally to this work with: Michael L. Forbes, Edward Horsey

Current address: Critical Care Division, Children's Hospital Medical Center of Akron, Akron, Ohio, United States of America

Affiliations Department of Pediatrics, Allegheny General Hospital, Pittsburgh, Pennsylvania, United States of America, Center for Genomic Sciences, Allegheny General Hospital-Allegheny-Singer Research Institute, Pittsburgh, Pennsylvania, United States of America
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Edward Horsey ,

Contributed equally to this work with: Michael L. Forbes, Edward Horsey

Affiliation Center for Genomic Sciences, Allegheny General Hospital-Allegheny-Singer Research Institute, Pittsburgh, Pennsylvania, United States of America
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N. Luisa Hiller,

Affiliation Center for Genomic Sciences, Allegheny General Hospital-Allegheny-Singer Research Institute, Pittsburgh, Pennsylvania, United States of America
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Farrel J. Buchinsky,

Affiliations Center for Genomic Sciences, Allegheny General Hospital-Allegheny-Singer Research Institute, Pittsburgh, Pennsylvania, United States of America, Department of Surgery, Allegheny General Hospital, Pittsburgh, Pennsylvania, United States of America, Department of Microbiology and Immunology, Drexel University College of Medicine, Pittsburgh, Pennsylvania, United States of America
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Jay D. Hayes,

Affiliation Center for Genomic Sciences, Allegheny General Hospital-Allegheny-Singer Research Institute, Pittsburgh, Pennsylvania, United States of America
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James M. Compliment,

Affiliation Center for Genomic Sciences, Allegheny General Hospital-Allegheny-Singer Research Institute, Pittsburgh, Pennsylvania, United States of America
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Todd Hillman,

Affiliations Center for Genomic Sciences, Allegheny General Hospital-Allegheny-Singer Research Institute, Pittsburgh, Pennsylvania, United States of America, Department of Neurosurgery, Allegheny General Hospital, Pittsburgh, Pennsylvania, United States of America
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Suzanne Ezzo,

Affiliation Center for Genomic Sciences, Allegheny General Hospital-Allegheny-Singer Research Institute, Pittsburgh, Pennsylvania, United States of America
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Kai Shen,

Affiliation Center for Genomic Sciences, Allegheny General Hospital-Allegheny-Singer Research Institute, Pittsburgh, Pennsylvania, United States of America
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Randy Keefe,

Affiliation Center for Genomic Sciences, Allegheny General Hospital-Allegheny-Singer Research Institute, Pittsburgh, Pennsylvania, United States of America
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Karen Barbadora,

Affiliation Department of Pediatrics, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
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J. Christopher Post,

Affiliations Center for Genomic Sciences, Allegheny General Hospital-Allegheny-Singer Research Institute, Pittsburgh, Pennsylvania, United States of America, Department of Surgery, Allegheny General Hospital, Pittsburgh, Pennsylvania, United States of America, Department of Microbiology and Immunology, Drexel University College of Medicine, Pittsburgh, Pennsylvania, United States of America
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Fen Ze Hu,

Affiliations Center for Genomic Sciences, Allegheny General Hospital-Allegheny-Singer Research Institute, Pittsburgh, Pennsylvania, United States of America, Department of Microbiology and Immunology, Drexel University College of Medicine, Pittsburgh, Pennsylvania, United States of America
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Garth D. Ehrlich

*To whom correspondence should be addressed. E-mail: gehrlich@wpahs.org

Affiliations Center for Genomic Sciences, Allegheny General Hospital-Allegheny-Singer Research Institute, Pittsburgh, Pennsylvania, United States of America, Department of Microbiology and Immunology, Drexel University College of Medicine, Pittsburgh, Pennsylvania, United States of America
⨯

Strain-Specific Virulence Phenotypes of Streptococcus pneumoniae Assessed Using the Chinchilla laniger Model of Otitis Media

Michael L. Forbes,
Edward Horsey,
N. Luisa Hiller,
Farrel J. Buchinsky,
Jay D. Hayes,
James M. Compliment,
Todd Hillman,
Suzanne Ezzo,
Kai Shen,
Randy Keefe

Published: April 9, 2008
https://doi.org/10.1371/journal.pone.0001969

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