SIRT1 Overexpression Antagonizes Cellular Senescence with Activated ERK/S6k1 Signaling in Human Diploid Fibroblasts

Jing Huang; Qini Gan; Limin Han; Jian Li; Hai Zhang; Ying Sun; Zongyu Zhang; Tanjun Tong

doi:10.1371/journal.pone.0001710

Loading metrics

Open Access

Peer-reviewed

Research Article

SIRT1 Overexpression Antagonizes Cellular Senescence with Activated ERK/S6k1 Signaling in Human Diploid Fibroblasts

Jing Huang,

Affiliations Peking University Research Center on Aging, Beijing, People's Republic of China, Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing, People's Republic of China
⨯
Qini Gan,

Affiliations Peking University Research Center on Aging, Beijing, People's Republic of China, Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing, People's Republic of China
⨯
Limin Han,

Affiliations Peking University Research Center on Aging, Beijing, People's Republic of China, Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing, People's Republic of China
⨯
Jian Li,

Affiliations Peking University Research Center on Aging, Beijing, People's Republic of China, Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing, People's Republic of China
⨯
Hai Zhang,

Affiliations Peking University Research Center on Aging, Beijing, People's Republic of China, Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing, People's Republic of China
⨯
Ying Sun,

Affiliations Peking University Research Center on Aging, Beijing, People's Republic of China, Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing, People's Republic of China
⨯
Zongyu Zhang,

Affiliations Peking University Research Center on Aging, Beijing, People's Republic of China, Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing, People's Republic of China
⨯
Tanjun Tong

*To whom correspondence should be addressed. E-mail: tztong@bjmu.edu.cn

Affiliations Peking University Research Center on Aging, Beijing, People's Republic of China, Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing, People's Republic of China
⨯

SIRT1 Overexpression Antagonizes Cellular Senescence with Activated ERK/S6k1 Signaling in Human Diploid Fibroblasts

Jing Huang,
Qini Gan,
Limin Han,
Jian Li,
Hai Zhang,
Ying Sun,
Zongyu Zhang,
Tanjun Tong

Published: March 5, 2008
https://doi.org/10.1371/journal.pone.0001710

Reader Comments (5)

Post a new comment on this article

0 Responses

27 Nov 2009
08:40 GMT
Most Recent

Cited by Posted by tztong on 27 Nov 2009 at 08:40 GMT
0 Responses

21 Aug 2009
09:28 GMT
Most Recent

Cited by: Posted by tztong on 21 Aug 2009 at 09:28 GMT
0 Responses

23 Jul 2009
07:05 GMT
Most Recent

Cited by: Posted by tztong on 23 Jul 2009 at 07:05 GMT
0 Responses

05 Jun 2008
09:09 GMT
Most Recent

Cell aging: The pathway to eternal youth Posted by tztong on 05 Jun 2008 at 09:09 GMT
0 Responses

05 Jun 2008
09:06 GMT
Most Recent

Cell aging: The pathway to eternal youth Posted by tztong on 05 Jun 2008 at 09:06 GMT

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Fibroblasts
Is the Subject Area "Fibroblasts" applicable to this article?

Thanks for your feedback.
Senescence
Is the Subject Area "Senescence" applicable to this article?

Thanks for your feedback.
Phosphorylation
Is the Subject Area "Phosphorylation" applicable to this article?

Thanks for your feedback.
Transfection
Is the Subject Area "Transfection" applicable to this article?

Thanks for your feedback.
ERK signaling cascade
Is the Subject Area "ERK signaling cascade" applicable to this article?

Thanks for your feedback.
Cell proliferation
Is the Subject Area "Cell proliferation" applicable to this article?

Thanks for your feedback.
Cell staining
Is the Subject Area "Cell staining" applicable to this article?

Thanks for your feedback.
Hyperexpression techniques
Is the Subject Area "Hyperexpression techniques" applicable to this article?

Thanks for your feedback.