Inhibition of Chk1 Kills Tetraploid Tumor Cells through a p53-Dependent Pathway

Ilio Vitale; Lorenzo Galluzzi; Sonia Vivet; Lisa Nanty; Philippe Dessen; Laura Senovilla; Ken A. Olaussen; Vladimir Lazar; Michelle Prudhomme; Roy M. Golsteyn; Maria Castedo; Guido Kroemer

doi:10.1371/journal.pone.0001337

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Peer-reviewed

Research Article

Inhibition of Chk1 Kills Tetraploid Tumor Cells through a p53-Dependent Pathway

Ilio Vitale,

Affiliations INSERM, U848, Cancer and Immunity, Villejuif, France, Institut Gustave Roussy,Villejuif, France, Université Paris Sud-11, Villejuif, France
⨯
Lorenzo Galluzzi,

Affiliations INSERM, U848, Cancer and Immunity, Villejuif, France, Institut Gustave Roussy,Villejuif, France, Université Paris Sud-11, Villejuif, France
⨯
Sonia Vivet,

Affiliations INSERM, U848, Cancer and Immunity, Villejuif, France, Institut Gustave Roussy,Villejuif, France, Université Paris Sud-11, Villejuif, France
⨯
Lisa Nanty,

Affiliations INSERM, U848, Cancer and Immunity, Villejuif, France, Institut Gustave Roussy,Villejuif, France
⨯
Philippe Dessen,

Affiliations Institut Gustave Roussy,Villejuif, France, Université Paris Sud-11, Villejuif, France, Centre National de la Recherche Scientifique (CNRS), FRE2939, Villejuif, France, Unité de Génomique Fonctionnelle, Institut Gustave Roussy,Villejuif, France
⨯
Laura Senovilla,

Affiliations INSERM, U848, Cancer and Immunity, Villejuif, France, Institut Gustave Roussy,Villejuif, France, Université Paris Sud-11, Villejuif, France
⨯
Ken A. Olaussen,

Affiliations INSERM, U848, Cancer and Immunity, Villejuif, France, Institut Gustave Roussy,Villejuif, France, Université Paris Sud-11, Villejuif, France
⨯
Vladimir Lazar,

Affiliations Institut Gustave Roussy,Villejuif, France, Université Paris Sud-11, Villejuif, France, Centre National de la Recherche Scientifique (CNRS), FRE2939, Villejuif, France, Unité de Génomique Fonctionnelle, Institut Gustave Roussy,Villejuif, France
⨯
Michelle Prudhomme,

Affiliation Université Blaise Pascal, Synthèse et Etude de Systèmes à Intérêt Biologique, UMR 6504 Centre National de la Recherche Scientifique (CNRS), Aubière, France
⨯
Roy M. Golsteyn,

Affiliation Institut de Recherche Servier, Croissy sur Seine, France
⨯
Maria Castedo ,

Contributed equally to this work with: Maria Castedo, Guido Kroemer

Affiliations INSERM, U848, Cancer and Immunity, Villejuif, France, Institut Gustave Roussy,Villejuif, France, Université Paris Sud-11, Villejuif, France
⨯
Guido Kroemer

Contributed equally to this work with: Maria Castedo, Guido Kroemer

*To whom correspondence should be addressed. E-mail: kroemer@igr.fr

Affiliations INSERM, U848, Cancer and Immunity, Villejuif, France, Institut Gustave Roussy,Villejuif, France, Université Paris Sud-11, Villejuif, France
⨯

Inhibition of Chk1 Kills Tetraploid Tumor Cells through a p53-Dependent Pathway

Ilio Vitale,
Lorenzo Galluzzi,
Sonia Vivet,
Lisa Nanty,
Philippe Dessen,
Laura Senovilla,
Ken A. Olaussen,
Vladimir Lazar,
Michelle Prudhomme,
Roy M. Golsteyn

Published: December 26, 2007
https://doi.org/10.1371/journal.pone.0001337

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Tetraploidy
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Small interfering RNA
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Transfection
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Apoptosis
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Cell staining
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Mitosis
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Phosphorylation
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Histones
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