Exchanging Murine and Human Immunoglobulin Constant Chains Affects the Kinetics and Thermodynamics of Antigen Binding and Chimeric Antibody Autoreactivity

• Marcela Torres,

  Current address: Regeneron Pharmaceuticals, Tarrytown, New York, United States of America

  Affiliation Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, United States of America

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• Narcis Fernandez-Fuentes,

  Current address: Leeds Institute of Molecular Medicine, Section of Experimental Therapeutics, St. James's Hospital, Leeds, United Kingdom

  Affiliation Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, United States of America

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• András Fiser,

  Affiliation Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, United States of America

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• Arturo Casadevall

  *To whom correspondence should be addressed. E-mail: casadeva@aecom.yu.edu.

  Affiliation Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, United States of America

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