High CO2 Levels Impair Alveolar Epithelial Function Independently of pH

Arturo Briva; István Vadász; Emilia Lecuona; Lynn C. Welch; Jiwang Chen; Laura A. Dada; Humberto E. Trejo; Vidas Dumasius; Zaher S. Azzam; Pavlos M. Myrianthefs; Daniel Batlle; Yosef Gruenbaum; Jacob I. Sznajder

doi:10.1371/journal.pone.0001238

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Open Access

Peer-reviewed

Research Article

High CO₂ Levels Impair Alveolar Epithelial Function Independently of pH

Arturo Briva,

Affiliations Division of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America, Departamento de Fisiopatología, Facultad de Medicina, Universidad de la Republica, Montevideo, Uruguay
⨯
István Vadász,

Affiliations Division of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America, University of Giessen Lung Center, Justus Liebig University, Giessen, Germany
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Emilia Lecuona,

Affiliation Division of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America
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Lynn C. Welch,

Affiliation Division of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America
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Jiwang Chen,

Affiliation Division of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America
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Laura A. Dada,

Affiliation Division of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America
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Humberto E. Trejo,

Affiliation Division of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America
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Vidas Dumasius,

Affiliation Division of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America
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Zaher S. Azzam,

Affiliations Division of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America, Ruth & Bruce Rappaport Faculty of Medicine and Research Institute, Technion-Israel Institute of Technology, Haifa, Israel
⨯
Pavlos M. Myrianthefs,

Affiliations Division of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America, Intensive Care Unit, Athens University, “KAT” General Hospital, Athens, Greece
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Daniel Batlle,

Affiliation Division of Nephrology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America
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Yosef Gruenbaum,

Affiliations Division of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America, Department of Genetics, Hebrew University of Jerusalem, Jerusalem, Israel
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Jacob I. Sznajder

*To whom correspondence should be addressed. E-mail: j-sznajder@northwestern.edu

Affiliation Division of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America
⨯

High CO₂ Levels Impair Alveolar Epithelial Function Independently of pH

Arturo Briva,
István Vadász,
Emilia Lecuona,
Lynn C. Welch,
Jiwang Chen,
Laura A. Dada,
Humberto E. Trejo,
Vidas Dumasius,
Zaher S. Azzam,
Pavlos M. Myrianthefs

Published: November 28, 2007
https://doi.org/10.1371/journal.pone.0001238

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07 Jul 2010
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Carbon dioxide
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Cell membranes
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Phosphorylation
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Protein abundance
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Acidosis
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Hypercapnia
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Endocytosis
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Epithelial cells
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