High Pro-Inflammatory Cytokine Secretion and Loss of High Avidity Cross-Reactive Cytotoxic T-Cells during the Course of Secondary Dengue Virus Infection

Tao Dong; Edward Moran; Nguyen Vinh Chau; Cameron Simmons; Kerstin Luhn; Yanchun Peng; Bridget Wills; Nguyen Phuong Dung; Le Thi Thu Thao; Tran Tinh Hien; Andrew McMichael; Jeremy Farrar; Sarah Rowland-Jones

doi:10.1371/journal.pone.0001192

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Open Access

Peer-reviewed

Research Article

High Pro-Inflammatory Cytokine Secretion and Loss of High Avidity Cross-Reactive Cytotoxic T-Cells during the Course of Secondary Dengue Virus Infection

Tao Dong ,

Contributed equally to this work with: Tao Dong, Edward Moran

*To whom correspondence should be addressed. E-mail: tao.dong@imm.ox.ac.uk (TD); edward.moran@imm.ox.ac.uk (EM)

Affiliation MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
⨯
Edward Moran ,

Contributed equally to this work with: Tao Dong, Edward Moran

*To whom correspondence should be addressed. E-mail: tao.dong@imm.ox.ac.uk (TD); edward.moran@imm.ox.ac.uk (EM)

Affiliation MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
⨯
Nguyen Vinh Chau,

Affiliation Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam
⨯
Cameron Simmons,

Affiliation Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam
⨯
Kerstin Luhn,

Affiliation MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
⨯
Yanchun Peng,

Affiliation MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
⨯
Bridget Wills,

Affiliation Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam
⨯
Nguyen Phuong Dung,

Affiliation Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam
⨯
Le Thi Thu Thao,

Affiliation Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam
⨯
Tran Tinh Hien,

Affiliation Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam
⨯
Andrew McMichael,

Affiliation MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
⨯
Jeremy Farrar,

Affiliation Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam
⨯
Sarah Rowland-Jones

Affiliation MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, United Kingdom
⨯

High Pro-Inflammatory Cytokine Secretion and Loss of High Avidity Cross-Reactive Cytotoxic T-Cells during the Course of Secondary Dengue Virus Infection

Tao Dong,
Edward Moran,
Nguyen Vinh Chau,
Cameron Simmons,
Kerstin Luhn,
Yanchun Peng,
Bridget Wills,
Nguyen Phuong Dung,
Le Thi Thu Thao,
Tran Tinh Hien

Published: December 5, 2007
https://doi.org/10.1371/journal.pone.0001192

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