Targeting Thioredoxin Reductase 1 Reduction in Cancer Cells Inhibits Self-Sufficient Growth and DNA Replication

Min-Hyuk Yoo; Xue-Ming Xu; Bradley A. Carlson; Andrew D. Patterson; Vadim N. Gladyshev; Dolph L. Hatfield

doi:10.1371/journal.pone.0001112

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Peer-reviewed

Research Article

Targeting Thioredoxin Reductase 1 Reduction in Cancer Cells Inhibits Self-Sufficient Growth and DNA Replication

Min-Hyuk Yoo,

Affiliation Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Xue-Ming Xu,

Affiliation Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Bradley A. Carlson,

Affiliation Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
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Andrew D. Patterson,

Current address: Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

Affiliation Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Vadim N. Gladyshev,

Affiliation Department of Biochemistry, University of Nebraska, Lincoln, Nebraska, United States of America
⨯
Dolph L. Hatfield

*To whom correspondence should be addressed. E-mail: hatfield@mail.nih.gov

Affiliation Molecular Biology of Selenium Section, Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
⨯

Targeting Thioredoxin Reductase 1 Reduction in Cancer Cells Inhibits Self-Sufficient Growth and DNA Replication

Min-Hyuk Yoo,
Xue-Ming Xu,
Bradley A. Carlson,
Andrew D. Patterson,
Vadim N. Gladyshev,
Dolph L. Hatfield

Published: October 31, 2007
https://doi.org/10.1371/journal.pone.0001112

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Lung and intrathoracic tumors
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DNA replication
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