Targeted Deletion of HIF-1α Gene in T Cells Prevents their Inhibition in Hypoxic Inflamed Tissues and Improves Septic Mice Survival

• Manfred Thiel ,

  Contributed equally to this work with: Manfred Thiel, Charles C. Caldwell

  Affiliations Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America, Department of Anaesthesiology, Klinikum Grosshadern, University of Munich, Munich, Germany

  ⨯
• Charles C. Caldwell ,

  Contributed equally to this work with: Manfred Thiel, Charles C. Caldwell

  Affiliations Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America, Trauma, Sepsis and Inflammation Research Group, Department of Surgery, College of Medicine, University of Cincinnati, Cincinnati, Ohio, United States of America, Department of Research, Shriner's Hospital for Children, Cincinnati, Ohio, United States of America

  ⨯
• Simone Kreth,

  Affiliation Department of Anaesthesiology, Klinikum Grosshadern, University of Munich, Munich, Germany

  ⨯
• Satoshi Kuboki,

  Affiliation Trauma, Sepsis and Inflammation Research Group, Department of Surgery, College of Medicine, University of Cincinnati, Cincinnati, Ohio, United States of America

  ⨯
• P. Chen,

  Affiliation Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

  ⨯
• Patrick Smith,

  Affiliation Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

  ⨯
• Akio Ohta,

  Affiliations Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America, New England Inflammation and Tissue Protection Institute, Northeastern University, Boston, Massachusetts, United States of America

  ⨯
• Alex B. Lentsch,

  Affiliation Trauma, Sepsis and Inflammation Research Group, Department of Surgery, College of Medicine, University of Cincinnati, Cincinnati, Ohio, United States of America

  ⨯
• Dmitry Lukashev,

  Affiliations Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America, New England Inflammation and Tissue Protection Institute, Northeastern University, Boston, Massachusetts, United States of America

  ⨯
• Michail V. Sitkovsky

  *To whom correspondence should be addressed. E-mail: m.sitkovsky@neu.edu

  Affiliations Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America, New England Inflammation and Tissue Protection Institute, Northeastern University, Boston, Massachusetts, United States of America

  ⨯