Characterization of an Enantioselective Odorant Receptor in the Yellow Fever Mosquito Aedes aegypti

Jonathan D. Bohbot; Joseph C. Dickens

doi:10.1371/journal.pone.0007032

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Research Article

Characterization of an Enantioselective Odorant Receptor in the Yellow Fever Mosquito Aedes aegypti

Jonathan D. Bohbot,

Affiliation United States Department of Agriculture, Agricultural Research Service, Henry A. Wallace Beltsville Agricultural Research Center, Plant Sciences Institute, Invasive Insect Biocontrol and Behavior Laboratory, Beltsville, Maryland, United States of America
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Joseph C. Dickens

* E-mail: joseph.dickens@ars.usda.gov

Affiliation United States Department of Agriculture, Agricultural Research Service, Henry A. Wallace Beltsville Agricultural Research Center, Plant Sciences Institute, Invasive Insect Biocontrol and Behavior Laboratory, Beltsville, Maryland, United States of America
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Characterization of an Enantioselective Odorant Receptor in the Yellow Fever Mosquito Aedes aegypti

Jonathan D. Bohbot,
Joseph C. Dickens

Published: September 15, 2009
https://doi.org/10.1371/journal.pone.0007032

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Biological implications and the possibility of second site interactions?

Posted by David_Rinker on 16 Sep 2009 at 19:36 GMT

Do you attribute a biologic significance to AaOR8's ability to distinguish between these two enantomers? For example, what exactly is known about natural sources of 1-octen-3-ol and their respective entanomeric compositions? The article mentions a cattle study from 1984, but can we say that there is a more general trend that favors one form over the other?

Secondly, regarding the structure/activity relationship, have you considered looking at the possibility of allostericity? It could be possible that the two enantiomers interact with different sites on the receptor.

No competing interests declared.

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Characterization of an Enantioselective Odorant Receptor in the Yellow Fever Mosquito Aedes aegypti

Characterization of an Enantioselective Odorant Receptor in the Yellow Fever Mosquito Aedes aegypti

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Biological implications and the possibility of second site interactions?

Posted by David_Rinker on 16 Sep 2009 at 19:36 GMT