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closeWhat's the nature of these mutations?
Posted by dfoo167 on 05 Aug 2011 at 01:18 GMT
accumulated mutations
http://plosone.org/article/info:doi/10.1371/journal.pone.0013180#article1.body1.sec2.sec2.p1
Are they loss-of-function or gain-of-function mutations?
RE: What's the nature of these mutations?
cuiqinghua replied to dfoo167 on 05 Aug 2011 at 11:28 GMT
I don't know what your "these mutations" refer to. are they "co-occurring" and "anti-co-occurring"? you can not simply named they are loss-of -function or gain-of-function, like single gene. they are paired.
but in my opinion, co-occurring mutations may mean one single mutaiton is not enough to initiate tumor.
RE: What's the nature of these mutations?
dfoo167 replied to cuiqinghua on 16 Oct 2011 at 23:37 GMT
Let me re-phrase my question. Are the co-occurring mutations pairs of loss-of-function mutations or pairs of gain-of-function mutations? Furthermore, are the co-occurring mutations pairs of driver genes known to co-occur at the early stages of cancer?