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closeThis May be Caused by Reduced DHEA caused by Testosterone
Posted by jamesmhoward on 18 Oct 2016 at 09:37 GMT
I suggest the basis of the findings of Hsu, et al., is the effects of testosterone on dehydroepiandrosterone (DHEA) levels. ("AIDS & Dehydroepiandrosterone," at: http://anthropogeny.com/A... )
In 1985 I first suggested that vulnerability to the HIV, not called this at the time, is caused by low DHEA which reduces the immune response. As far as I can determine, the first reports of low DHEA in HIV / AIDS appeared around 1989.
Regarding Hsu, et al., it is part of my work that testosterone reduces available DHEA. DHEA is known to be lower in homosexual men than heterosexual men (see third chart at the link above). Therefore, vulnerability to the HIV, and other infectious agents, in homosexual men is increased because of low DHEA and high testosterone.
I suggest the foregoing may explain the findings of Hsu, et al., including increased cancer formation: It is my hypothesis of 1994 that increased testosterone increases breast cancer, as well as other cancers in men and women (International Journal of Cancer 2005; 115: 497) because low DHEA may be the trigger for cancer initiation: In 1994, I first suggested that low DHEA is directly involved in initiation of oncogenes: "An Explanation of Cancer and the Increase in Cancer: High Testosterone, Low DHEA and Breast Cancer," at: http://anthropogeny.com/A... which appeared first in publication: Annals of Internal Medicine 2005; 142: 471-472 . This also explains why breast cancer is increasing; it is my hypothesis that women of higher testosterone are increasing in percentage within the population with time. This effect involves testosterone's effects on levels of dehydroepiandrosterone (DHEA). That is, testosterone reduces overall availability of DHEA because testosterone reduces steroid sulfatase. (Biochimica et Biophysica Acta (BBA) - Enzymology Volume 258, Issue 2, 28 February 1972, Pages 473-483). If DHEAS, the precursor of DHEA, is high, DHEA is not being made.