Multiple Sleep Alterations in Mice Lacking Cannabinoid Type 1 Receptors

Alessandro Silvani; Chiara Berteotti; Stefano Bastianini; Viviana Lo Martire; Roberta Mazza; Uberto Pagotto; Carmelo Quarta; Giovanna Zoccoli

doi:10.1371/journal.pone.0089432

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Multiple Sleep Alterations in Mice Lacking Cannabinoid Type 1 Receptors

Alessandro Silvani ,

Contributed equally to this work with: Alessandro Silvani, Chiara Berteotti

Affiliation PRISM lab, Department of Biomedical and Neuromotor Sciences, Alma Mater Studiorum – University of Bologna, Bologna, Italy
⨯
Chiara Berteotti ,

Contributed equally to this work with: Alessandro Silvani, Chiara Berteotti

Affiliation PRISM lab, Department of Biomedical and Neuromotor Sciences, Alma Mater Studiorum – University of Bologna, Bologna, Italy
⨯
Stefano Bastianini,

Affiliation PRISM lab, Department of Biomedical and Neuromotor Sciences, Alma Mater Studiorum – University of Bologna, Bologna, Italy
⨯
Viviana Lo Martire,

Affiliation PRISM lab, Department of Biomedical and Neuromotor Sciences, Alma Mater Studiorum – University of Bologna, Bologna, Italy
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Roberta Mazza,

Affiliation Endocrinology Unit and Center for Applied Biomedical Research, Department of Medical and Surgical Sciences, S. Orsola University Hospital, Alma Mater Studiorum – University of Bologna, Bologna, Italy
⨯
Uberto Pagotto,

Affiliation Endocrinology Unit and Center for Applied Biomedical Research, Department of Medical and Surgical Sciences, S. Orsola University Hospital, Alma Mater Studiorum – University of Bologna, Bologna, Italy
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Carmelo Quarta,

Affiliation Endocrinology Unit and Center for Applied Biomedical Research, Department of Medical and Surgical Sciences, S. Orsola University Hospital, Alma Mater Studiorum – University of Bologna, Bologna, Italy
⨯
Giovanna Zoccoli

* E-mail: giovanna.zoccoli@unibo.it

Affiliation PRISM lab, Department of Biomedical and Neuromotor Sciences, Alma Mater Studiorum – University of Bologna, Bologna, Italy
⨯

Multiple Sleep Alterations in Mice Lacking Cannabinoid Type 1 Receptors

Alessandro Silvani,
Chiara Berteotti,
Stefano Bastianini,
Viviana Lo Martire,
Roberta Mazza,
Uberto Pagotto,
Carmelo Quarta,
Giovanna Zoccoli

Published: February 20, 2014
https://doi.org/10.1371/journal.pone.0089432

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Sleep in Mice Lacking Cannabinoid Type 1 Receptors

Posted by AlessandroSilvani on 26 Sep 2014 at 10:03 GMT

Interested PLOS ONE readers may find it useful to compare the results of our paper with those of the paper entitled “Endocannabinoid Modulation of Cortical Up-States and NREM Sleep” by M.J. Pava and coworkers, which was published on this Journal almost simultaneously with ours (PLOS ONE 2014;9:e88672). The results of the study by Pava and coworkers differed from those of ours in terms of the architecture and electroencephalographic features of non-rapid-eye-movement (NREM) sleep and the regulation of rapid-eye-movement (REM) sleep in mice lacking CB1 cannabinoid receptors. These issues should thus be considered as somewhat unsettled. On the other hand, our study and that of Pava et al. consistently showed that CB1-KO mice lacking CB1 cannabinoid receptors spent more time in wakefulness and less time in non-rapid-eye-movement (NREM) sleep during the dark (active) period of the day than did the wild-type mice. This concordance of independent results lends support to the view that CB1 cannabinoid receptors play a role in regulating the propensity to arousal during the active period of the day.

Alessandro Silvani

No competing interests declared.

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Multiple Sleep Alterations in Mice Lacking Cannabinoid Type 1 Receptors

Multiple Sleep Alterations in Mice Lacking Cannabinoid Type 1 Receptors

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Sleep in Mice Lacking Cannabinoid Type 1 Receptors

Posted by AlessandroSilvani on 26 Sep 2014 at 10:03 GMT