Sudden Cardiac Death (SCD) in early adulthood is a dramatic event. However, according to your results, only 4.2% (38 of 903 deceased) suffered from HCM. Unfortunately, there is no information for almost 96% of those who died of SCD.
Sudden cardiac deaths have increased in association with Covid-19 and the vaccination campaign underway since 2021. Their findings from 2000-2010 provide part of the database for an appropriate comparison, which should definitely be made.
There is a plausible hypothesis for the SCD increase. The nonneutralized S1 subunit of SARS-CoViruses or spike-based vaccines binds with its RBD to its receptor enzyme ACE2, thereby reducing its protective role in the renin-angiotensin-aldosterone system (RAAS) and triggering disinhibition of pathophysiologically deleterious RAAS effects. Countless corresponding adverse effects in the cardiovascular and other organ systems have long been known (KJ Lehmann: Suspected Cardiovascular Side Effects of Two COVID-19 Vaccines, J. of Biology and Todays World 2021, Vol 10, Issue 5: 001-006; KJ Lehmann: Spike-Induced Disturbances (SPAS*): An Analysis of Common Suspected Adverse Experiences Associated With Covid-19 Vaccines, International Journal of Infectious Diseases and Research 2022, 3(1); 1-19).
This hypothesis also provides an explanation for the so-called broken heart syndrome.
I would therefore encourage the following research:
- Comparison of SCD incidence since the start of spike-based Covid-19 drug/vaccine vaccinations with SCD incidence in the years 2000-2010 in young adults.
- Inclusion of markers of an activated RAAS (humoral and tissue) and of catecholamines in the studies
- Detection of spike subunit S1 in cardiac tissue in vaccinated SCD deceased.