Tramadol and Propentofylline Coadministration Exerted Synergistic Effects on Rat Spinal Nerve Ligation-Induced Neuropathic Pain

Jin Zhang; Dan Wu; Cheng Xie; Huan Wang; Wei Wang; Hui Zhang; Rui Liu; Li-Xian Xu; Xiao-Peng Mei

doi:10.1371/journal.pone.0072943

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Open Access

Peer-reviewed

Research Article

Tramadol and Propentofylline Coadministration Exerted Synergistic Effects on Rat Spinal Nerve Ligation-Induced Neuropathic Pain

Jin Zhang ,

Contributed equally to this work with: Jin Zhang, Dan Wu, Cheng Xie

Affiliation Department of Anesthesiology, School of Stomatology, Fourth Military Medical University, Xi'an, China
⨯
Dan Wu ,

Contributed equally to this work with: Jin Zhang, Dan Wu, Cheng Xie

Affiliation Department of Prosthodontics, School of Stomatology, Fourth Military Medical University, Xi'an, China
⨯
Cheng Xie ,

Contributed equally to this work with: Jin Zhang, Dan Wu, Cheng Xie

Affiliation Department of Prosthodontics, School of Stomatology, Fourth Military Medical University, Xi'an, China
⨯
Huan Wang,

Affiliation Department of Orthodontics, School of Stomatology, Fourth Military Medical University, Xi'an, China
⨯
Wei Wang,

Affiliation Department of Anesthesiology, School of Stomatology, Fourth Military Medical University, Xi'an, China
⨯
Hui Zhang,

Affiliation Department of Anesthesiology, School of Stomatology, Fourth Military Medical University, Xi'an, China
⨯
Rui Liu ,

* E-mail: liuruiliurui1976@126.com (RL); kqmzk@126.com (LXX); meixiaopengmxp@126.com (XPM)

Affiliation Department of Anesthesiology, School of Stomatology, Fourth Military Medical University, Xi'an, China
⨯
Li-Xian Xu ,

* E-mail: liuruiliurui1976@126.com (RL); kqmzk@126.com (LXX); meixiaopengmxp@126.com (XPM)

Affiliation Department of Anesthesiology, School of Stomatology, Fourth Military Medical University, Xi'an, China
⨯
Xiao-Peng Mei

* E-mail: liuruiliurui1976@126.com (RL); kqmzk@126.com (LXX); meixiaopengmxp@126.com (XPM)

Affiliation Department of Anesthesiology, School of Stomatology, Fourth Military Medical University, Xi'an, China
⨯

Tramadol and Propentofylline Coadministration Exerted Synergistic Effects on Rat Spinal Nerve Ligation-Induced Neuropathic Pain

Jin Zhang,
Dan Wu,
Cheng Xie,
Huan Wang,
Wei Wang,
Hui Zhang,
Rui Liu,
Li-Xian Xu,
Xiao-Peng Mei

Published: August 29, 2013
https://doi.org/10.1371/journal.pone.0072943

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ED50 calculation error

Posted by drpetergrace on 14 Oct 2013 at 21:17 GMT

Zhang et al. state that the ED50 = 50% antiallodynia, but this is wrong: ED50 = 50% of Emax. As anti-allodynia is a percentage of the von Frey threshold range in the saline treated group, this assumes that Emax for both tramadol and PPF is 100% anti-allodynia, which has not been demonstrated by the authors and is unlikely to be true. Hence, the interaction calculation is based on false values.

No competing interests declared.

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Tramadol and Propentofylline Coadministration Exerted Synergistic Effects on Rat Spinal Nerve Ligation-Induced Neuropathic Pain

Tramadol and Propentofylline Coadministration Exerted Synergistic Effects on Rat Spinal Nerve Ligation-Induced Neuropathic Pain

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ED50 calculation error

Posted by drpetergrace on 14 Oct 2013 at 21:17 GMT