Systemic Bisperoxovanadium Activates Akt/mTOR, Reduces Autophagy, and Enhances Recovery following Cervical Spinal Cord Injury

Chandler L. Walker; Melissa J. Walker; Nai-Kui Liu; Emelie C. Risberg; Xiang Gao; Jinhui Chen; Xiao-Ming Xu

doi:10.1371/journal.pone.0030012

Loading metrics

Open Access

Peer-reviewed

Research Article

Systemic Bisperoxovanadium Activates Akt/mTOR, Reduces Autophagy, and Enhances Recovery following Cervical Spinal Cord Injury

Chandler L. Walker,

Affiliations Department of Anatomy and Cell Biology, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana, United States of America, Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
⨯
Melissa J. Walker,

Affiliations Medical Neuroscience Graduate Program, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana, United States of America, Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
⨯
Nai-Kui Liu,

Affiliation Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
⨯
Emelie C. Risberg,

Affiliation Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
⨯
Xiang Gao,

Affiliation Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
⨯
Jinhui Chen,

Affiliation Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
⨯
Xiao-Ming Xu

* E-mail: xu26@iupui.edu

Affiliations Department of Anatomy and Cell Biology, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana, United States of America, Medical Neuroscience Graduate Program, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana, United States of America, Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
⨯

Systemic Bisperoxovanadium Activates Akt/mTOR, Reduces Autophagy, and Enhances Recovery following Cervical Spinal Cord Injury

Chandler L. Walker,
Melissa J. Walker,
Nai-Kui Liu,
Emelie C. Risberg,
Xiang Gao,
Jinhui Chen,
Xiao-Ming Xu

Published: January 10, 2012
https://doi.org/10.1371/journal.pone.0030012

Reader Comments

Post a new comment on this article

Publisher's Note: Formatting error in text

Posted by PLOS_ONE_Group on 01 Feb 2012 at 20:55 GMT

400 ìg/kg bpV(pic)
http://plosone.org/article/info:doi/10.1371/journal.pone.0030012#article1.body1.sec2.sec2.p1

There was a formatting error in the second sentence of the Drug Treatment section of Materials and Methods. The correct text is, "400 µg/kg bpV(pic)."

No competing interests declared.

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Central nervous system
Is the Subject Area "Central nervous system" applicable to this article?

Thanks for your feedback.
Spinal cord injury
Is the Subject Area "Spinal cord injury" applicable to this article?

Thanks for your feedback.
Autophagic cell death
Is the Subject Area "Autophagic cell death" applicable to this article?

Thanks for your feedback.
Astrocytes
Is the Subject Area "Astrocytes" applicable to this article?

Thanks for your feedback.
Neurons
Is the Subject Area "Neurons" applicable to this article?

Thanks for your feedback.
Neuroprotectives
Is the Subject Area "Neuroprotectives" applicable to this article?

Thanks for your feedback.
Spinal cord
Is the Subject Area "Spinal cord" applicable to this article?

Thanks for your feedback.
Computer software
Is the Subject Area "Computer software" applicable to this article?

Thanks for your feedback.

Systemic Bisperoxovanadium Activates Akt/mTOR, Reduces Autophagy, and Enhances Recovery following Cervical Spinal Cord Injury

Systemic Bisperoxovanadium Activates Akt/mTOR, Reduces Autophagy, and Enhances Recovery following Cervical Spinal Cord Injury

Reader Comments

Post Your Discussion Comment

Why should this posting be reviewed?

Thank You!

Publisher's Note: Formatting error in text

Posted by PLOS_ONE_Group on 01 Feb 2012 at 20:55 GMT